@article{fdi:010020970,
  title = {{P}lasmodium falciparum clinical malaria : lessons from longitudinal studies in {S}enegal},
  author = {{R}ogier, {C}. and {T}all, {A}. and {D}iagne, {N}. and {F}ontenille, {D}idier and {S}piegel, {A}. and {T}rape, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{D}evelopment of new antimalaria strategies and particularly vaccines, needs an in-depth understanding of the relationships between transmission, infection, immunity, morbidity and mortality. {T}he intensive and longitudinal collection of entomological, parasitological and clinical data from the {S}enegalese populations of {D}ielmo (250-300 inhabitants), exposed to a perennial and intense transmission (about 200 infective bites/person/year), allows to respond to many questions about this subject. {T}he acquisition of an antimalaria immunity as one gets older appears to reduce parasite density, complexity of infection, risk of new patent infection after a suppressive treatment but does not reduce the prevalence (as assessed by {PCR}) of infection which is commonly chronic and asymptomatic. {T}he existence of a pyrogenic threshold effect of parasitaemia allows the individual diagnosis of malaria attacks. #{P}. falciparum$ genotyping suggests that successive malaria attacks are due to distinct recently inoculated parasite populations that multiply initially without restriction, a dominant population is generally responsible of the clinical manifestations and all new populations do not trigger systematically attacks. {T}he initial intensity of clinical manifestations does not differ perceptibly among children and adults, is not related to the duration of the attacks, does not allow the distinction between several types of attacks, is not predictive of their severity, and the clearance of parasites and manifestations is longer among youngest persons. {T}he risk of malaria attacks is lower as one gets older and among carriers of {AS} haemoglobin, is higher when transmission increases and during pregnancy up to three months after delivery, and vary between children. {T}he risk of malaria attack per infective bite is negatively related to the intensity of transmission... ({D}'apr{\`e}s r{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {PARASITE} ; {MORBIDITE} ; {EPIDEMIOLOGIE} ; {TRANSMISSION} ; {ETUDE} {REGIONALE} ; {INFECTION} ; {IMMUNITE} ; {DIAGNOSTIC} ; {ETUDE} {COMPARATIVE} ; {SENEGAL} ; {DIELMO} ; {NDIOP}},
  booktitle = {{T}he malaria challenge : after one hundred years of malariology},
  journal = {{P}arassitologia},
  volume = {41},
  numero = {1-3},
  pages = {255--259},
  ISSN = {0048-2951},
  year = {1999},
  URL = {https://www.documentation.ird.fr/hor/fdi:010020970},
}