%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Vanden Haesevelde, M.M.
%A Peeters, Martine
%A Jannes, G.
%A Janssens, W.
%A Van der Groen, G.
%A Sharp, P.M.
%A Saman, E.
%T Sequence analysis of a highly divergent HIV-1 related lentivirus isolated from a wild captured chimpanzee
%D 1996
%L fdi:010019141
%G ENG
%J Virology
%@ 0042-6822
%K SIDA ; VIRUS ; PRIMATE ; SINGE ; PHYLOGENIE ; GENOME ; ANALYSE GENETIQUE
%K SIV.VIRUS IMMUNODEFICIENCE SIMIENNE
%K ZAIRE
%N 221
%P 346-350
%R 10.1006/viro.1996.0384
%U https://www.documentation.ird.fr/hor/fdi:010019141
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_51-52/010019141.pdf
%W Horizon (IRD)
%X Two strains of simian immunodeficiency viruses (SIV) isolated from chimpanzees (SIVCPZ-GAB and SIVCPZ-GAB2) originating from Gabon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 (HIV-1). We describe the sequence analysis of a third HIV-1 related virus, SIVCPZ-ANT, isolated from a wild captured chimpanzee originating from Zaire. This virus displayed the same genetic organization as HIV-1 and was found to fall on the same lineage as HIV-1 and SIVCPZ-GAB. Protein sequence identity with SIVCPZ-GAB ranged from 72% (Pol) to 48% (Env) for the structural proteins, while a particularly divergent Vpu was found (only 25% identity to SIVCPZ-GAB). The V3 regions of the SIV-CPZ isolates were exceptionally conserved in contrast to the high divergence of V3 among HIV-1 isolates. However, SIVCPZ-ANT did not show a greater degree of sequence similarity with SIVCPZ-GAB than with HIV-1 isolates and represents a quite divergent outgroup of the HIV-1 lineage. Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic. (Résumé d'auteur)
%$ 052MALTRA03