@article{fdi:010019141,
  title = {{S}equence analysis of a highly divergent {HIV}-1 related lentivirus isolated from a wild captured chimpanzee},
  author = {{V}anden {H}aesevelde, {M}.{M}. and {P}eeters, {M}artine and {J}annes, {G}. and {J}anssens, {W}. and {V}an der {G}roen, {G}. and {S}harp, {P}.{M}. and {S}aman, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}wo strains of simian immunodeficiency viruses ({SIV}) isolated from chimpanzees ({SIVCPZ}-{GAB} and {SIVCPZ}-{GAB}2) originating from {G}abon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 ({HIV}-1). {W}e describe the sequence analysis of a third {HIV}-1 related virus, {SIVCPZ}-{ANT}, isolated from a wild captured chimpanzee originating from {Z}aire. {T}his virus displayed the same genetic organization as {HIV}-1 and was found to fall on the same lineage as {HIV}-1 and {SIVCPZ}-{GAB}. {P}rotein sequence identity with {SIVCPZ}-{GAB} ranged from 72% ({P}ol) to 48% ({E}nv) for the structural proteins, while a particularly divergent {V}pu was found (only 25% identity to {SIVCPZ}-{GAB}). {T}he {V}3 regions of the {SIV}-{CPZ} isolates were exceptionally conserved in contrast to the high divergence of {V}3 among {HIV}-1 isolates. {H}owever, {SIVCPZ}-{ANT} did not show a greater degree of sequence similarity with {SIVCPZ}-{GAB} than with {HIV}-1 isolates and represents a quite divergent outgroup of the {HIV}-1 lineage. {O}ur data suggest multiple introductions of {HIV}-1 in the human population and shed new light on the origin of the {HIV}-1 pandemic. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SIDA} ; {VIRUS} ; {PRIMATE} ; {SINGE} ; {PHYLOGENIE} ; {GENOME} ; {ANALYSE} {GENETIQUE} ; {SIV}.{VIRUS} {IMMUNODEFICIENCE} {SIMIENNE} ; {ZAIRE}},
  booktitle = {},
  journal = {{V}irology},
  numero = {221},
  pages = {346--350},
  ISSN = {0042-6822},
  year = {1996},
  DOI = {10.1006/viro.1996.0384},
  URL = {https://www.documentation.ird.fr/hor/fdi:010019141},
}