Garcia André auteur aut IRD Abel L. auteur aut IRD Cot Michel auteur aut IRD Richard P. auteur aut IRD Ranque Sophie auteur aut IRD Feingold J. auteur aut IRD Demenais F. auteur aut IRD Boussinesq Michel auteur aut IRD Chippaux Jean-Philippe auteur aut IRD text journalArticle eng text/pdf reformatted digital access Evidence is accumulating from experimental and human studies that genetic factors are involved both in the control of infectious diseases and in the regulation of infection levels and clinical presentation. So far few studies have investigated the role of these genetic factors in human infection by the filarial parasite Loa loa. We present a segregation analysis on 74 nuclear families who live in the tropical rainforest of southern Cameroun and are exposed to homogeneous loiasis transmission. The results indicate that there is a genetic predisposition to be microfilaraemic and that predisposed subjects might be genetically unable to mount an efficient immune response against loiasis antigens. This individual susceptibility could explain at least in part why the prevalence of infection (microfilaraemic individuals) does not usually exceed 30% of the exposed population in hyperendemic regions. Further genetic studies, based on linkage analysis using both familial information and genetic markers, will help to identify the nature of the genetic factors predising to microfilaraemia. (Résumé d'auteur) specialized FILARIOSE EPIDEMIOLOGIE VARIABILITE GENETIQUE IMMUNITE SENSIBILITE RESISTANCE PHENOTYPE FAMILLE ANALYSE GENETIQUE LOASE CAMEROUN SUD ZONE TROPICALE HUMIDE 052MALTRA05 4 8 565-574 1999 1360-2276 https://www.documentation.ird.fr/hor/fdi:010019036 10.1046/j.1365-3156.1999.00442.x 1360-2276 [F B010019036] https://www.documentation.ird.fr/hor/fdi:010019036 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_51-52/010019036.pdf IRD - Base Horizon / Pleins textes 1999-09-17 2018-06-15 fdi:010019036 fre