@article{fdi:010019036,
  title = {{G}enetic epidemiology of host predisposition microfilaraemia in human loiasis},
  author = {{G}arcia, {A}ndr{\'e} and {A}bel, {L}. and {C}ot, {M}ichel and {R}ichard, {P}. and {R}anque, {S}ophie and {F}eingold, {J}. and {D}emenais, {F}. and {B}oussinesq, {M}ichel and {C}hippaux, {J}ean-{P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{E}vidence is accumulating from experimental and human studies that genetic factors are involved both in the control of infectious diseases and in the regulation of infection levels and clinical presentation. {S}o far few studies have investigated the role of these genetic factors in human infection by the filarial parasite #{L}oa loa$. {W}e present a segregation analysis on 74 nuclear families who live in the tropical rainforest of southern {C}ameroun and are exposed to homogeneous loiasis transmission. {T}he results indicate that there is a genetic predisposition to be microfilaraemic and that predisposed subjects might be genetically unable to mount an efficient immune response against loiasis antigens. {T}his individual susceptibility could explain at least in part why the prevalence of infection (microfilaraemic individuals) does not usually exceed 30% of the exposed population in hyperendemic regions. {F}urther genetic studies, based on linkage analysis using both familial information and genetic markers, will help to identify the nature of the genetic factors predising to microfilaraemia. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{FILARIOSE} ; {EPIDEMIOLOGIE} ; {VARIABILITE} {GENETIQUE} ; {IMMUNITE} ; {SENSIBILITE} {RESISTANCE} ; {PHENOTYPE} ; {FAMILLE} ; {ANALYSE} {GENETIQUE} ; {LOASE} ; {CAMEROUN} {SUD} ; {ZONE} {TROPICALE} {HUMIDE}},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {4},
  numero = {8},
  pages = {565--574},
  ISSN = {1360-2276},
  year = {1999},
  DOI = {10.1046/j.1365-3156.1999.00442.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010019036},
}