Chandre Fabrice auteur aut IRD Darriet Frédéric auteur aut IRD Manguin Sylvie auteur aut IRD Brengues Cécile auteur aut IRD Carnevale Pierre auteur aut IRD Guillet Pierre auteur aut IRD text journalArticle eng text/pdf reformatted digital access Field samples of Anopheles gambiae s.s. from Côte d'Ivoire were tested with 5 pyrethroids (cyfluthrin, lambda-cyhalothrin, alpha-cypermethrin, deltamethrin, permethrin), 1 pseudo-pyrethroid (etofenprox), and an organochlorine (DDT). With the use of World Health Organization diagnostic tests, 5 out of 6 samples were found cross-resistant to these insecticides. A strong decrease in knockdown effect and mortality was also observed when testing deltamethrin-impregnated nettings. With a polymerase chain reaction amplification of specfic alleles diagnostic test, resistance was found associated with the presence of a kdr mutation. The strong correlation between kdr allelic frequency and resistance to DDT or etofenprox indicated that kdr was the main resistance factor for these 2 insecticides. On the contrary, a lower correlation was observed between kdr frequency and resistance to 4 of the 5 pyrethroids tested, suggesting that another mechanism was also involved, likely a metabolic detoxification. These results point out the necessity to monitor pyrethroid resistance and the presence of kdr before implementation of any impregnated bed-net programs for malaria control. (Résumé d'auteur) specialized SENSIBILITE RESISTANCE MOUSTIQUE VECTEUR INSECTICIDE CHIMIQUE TEST MOUSTIQUAIRE IMPREGNEE MECANISME DE RESISTANCE GENE MUTATION ETUDE EXPERIMENTALE PYRETHRINOIDE DDT GENE KDR COTE D'IVOIRE 052LUTIN03 15 1 53-59 1999 8756-971X https://www.documentation.ird.fr/hor/fdi:010018255 8756-971X [F B010018255] https://www.documentation.ird.fr/hor/fdi:010018255 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_49-50/010018255.pdf IRD - Base Horizon / Pleins textes 1999-07-16 2020-08-03 fdi:010018255 fre