Horizon 1 1 17 ACLN : Articles dans des revues avec comité de lecture non répertoriées par l'AERES Journal of the American Mosquito Control Association 53-59 SENSIBILITE RESISTANCE MOUSTIQUE VECTEUR INSECTICIDE CHIMIQUE TEST MOUSTIQUAIRE IMPREGNEE MECANISME DE RESISTANCE GENE MUTATION ETUDE EXPERIMENTALE PYRETHRINOIDE DDT GENE KDR COTE D'IVOIRE 1999 fdi:010018255 ENG Journal of the American Mosquito Control Association 8756-971X 1 https://www.documentation.ird.fr/hor/fdi:010018255 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_49-50/010018255.pdf 15 Horizon (IRD) Field samples of #Anopheles gambiae$ s.s. from Côte d'Ivoire were tested with 5 pyrethroids (cyfluthrin, lambda-cyhalothrin, alpha-cypermethrin, deltamethrin, permethrin), 1 pseudo-pyrethroid (etofenprox), and an organochlorine (DDT). With the use of World Health Organization diagnostic tests, 5 out of 6 samples were found cross-resistant to these insecticides. A strong decrease in knockdown effect and mortality was also observed when testing deltamethrin-impregnated nettings. With a polymerase chain reaction amplification of specfic alleles diagnostic test, resistance was found associated with the presence of a kdr mutation. The strong correlation between kdr allelic frequency and resistance to DDT or etofenprox indicated that kdr was the main resistance factor for these 2 insecticides. On the contrary, a lower correlation was observed between kdr frequency and resistance to 4 of the 5 pyrethroids tested, suggesting that another mechanism was also involved, likely a metabolic detoxification. These results point out the necessity to monitor pyrethroid resistance and the presence of kdr before implementation of any impregnated bed-net programs for malaria control. (Résumé d'auteur) 052LUTIN03