Pyrethroid cross resistance spectrum among populations of Anopheles gambiae s.s. from Côte d'Ivoire /Chandre, Fabrice /Darriet, Frédéric /Manguin, Sylvie /Brengues, Cécile /Carnevale, Pierre /Guillet, Pierre SENSIBILITE RESISTANCE MOUSTIQUE VECTEUR INSECTICIDE CHIMIQUE TEST MOUSTIQUAIRE IMPREGNEE MECANISME DE RESISTANCE GENE MUTATION ETUDE EXPERIMENTALE PYRETHRINOIDE DDT GENE KDR Field samples of Anopheles gambiae s.s. from Côte d'Ivoire were tested with 5 pyrethroids (cyfluthrin, lambda-cyhalothrin, alpha-cypermethrin, deltamethrin, permethrin), 1 pseudo-pyrethroid (etofenprox), and an organochlorine (DDT). With the use of World Health Organization diagnostic tests, 5 out of 6 samples were found cross-resistant to these insecticides. A strong decrease in knockdown effect and mortality was also observed when testing deltamethrin-impregnated nettings. With a polymerase chain reaction amplification of specfic alleles diagnostic test, resistance was found associated with the presence of a kdr mutation. The strong correlation between kdr allelic frequency and resistance to DDT or etofenprox indicated that kdr was the main resistance factor for these 2 insecticides. On the contrary, a lower correlation was observed between kdr frequency and resistance to 4 of the 5 pyrethroids tested, suggesting that another mechanism was also involved, likely a metabolic detoxification. These results point out the necessity to monitor pyrethroid resistance and the presence of kdr before implementation of any impregnated bed-net programs for malaria control. (Résumé d'auteur) 1999 text https://www.documentation.ird.fr/hor/fdi:010018255 fdi:010018255 Chandre Fabrice, Darriet Frédéric, Manguin Sylvie, Brengues Cécile, Carnevale Pierre, Guillet Pierre. Pyrethroid cross resistance spectrum among populations of Anopheles gambiae s.s. from Côte d'Ivoire. 1999, 15 (1), 53-59 EN COTE D'IVOIRE