@article{fdi:010017844,
  title = {{E}vidence for differences in {MT}2 cell tropism according to genetic subtypes of {HIV}-1 : syncytium-inducing variants seem rare among subtype {C} {HIV}-1 viruses},
  author = {{P}eeters, {M}artine and {V}incent, {R}. and {P}erret, {J}.{L}. and {L}asky, {M}ariama and {P}atrel, {D}elphine and {L}iegeois, {F}lorian and {C}ourgnaud, {V}. and {S}eng, {R}. and {M}atton, {T}. and {M}olinier, {S}. and {D}elaporte, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{N}on-syncytium-inducing ({NSI}) variants seem to be more readily transmitted than syncytium-inducing ({SI}) variants, and the switch from {NSI} to {SI} during {HIV}-1 infection seems to be a key determinant to the evolution of {AIDS}. {W}e investigated eventual differences in the {SI} capacity on {MT}-2 cells according to genetic subtypes of {HIV}-1 and correlated this observation with {CD}4 counts and duration of {HIV} infection. {I}n total, 86 patients, most with known date of {HIV} contamination and infected with different genetic subtypes, have been studied : 11 subtype {A}, 46 subtype {B}, 22 subtype {C}, and 7 subtype {E}. {M}ultivariate analysis used a {C}ox's proportional hazards regression. {T}he number and percentage of patients infected with an {SI} strain were as follows : 3 of 11 (27%) for subtype {A}, 15 of 46 (33%) for subtype {B}, 0 of 22 (0%) for subtype {C}, and 5 of 7 (71%) for subtype {E}. {A}fter adjustment for time after seroconversion and {CD}4 counts, significantly fewer {SI} variants were observed in patients infected with subtype {C} (p is less than .002) and it was found that subjects infected with subtype {E} had a higher risk of being infected with an {SI} strain (rate ratio ({RR}) = 12.39% ; 95% confidence interval ({CI}) 1.55-98.67 ; p is less than .001). {M}ost of the subtype {E}-infected patients from our study switched from an {NSI} to {SI} phenotype early after serconversion (less than 4 years). {T}o predict the in vitro presence of {SI} variants, we scanned {V}3-loop sequences for mutations at positions 11 and/or 25. {O}verall, 54 of 55 (98.2%) {NSI} strains in vitro were predicted {NSI}, and only 4 of 12 (33.3%) of {SI} viruses were predicted {SI}. {F}or patients in whom a switch from an {NSI} to an {SI} virus was observed, the {SI} phenotype could be detected earlier in vitro than by the corresponding {V}3-loop sequence... ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SIDA} ; {VIRUS} ; {VARIABILITE} {GENETIQUE} ; {PHENOTYPE} ; {EPIDEMIOLOGIE} ; {ETUDE} {COMPARATIVE} ; {ANALYSE} {STATISTIQUE} ; {VIH}-1},
  booktitle = {},
  journal = {{J}ournal of {A}cquired {I}mmune {D}eficiency {S}yndromes and {H}uman {R}etrovirology},
  volume = {20},
  numero = {2},
  pages = {115--121},
  ISSN = {1077-9450},
  year = {1999},
  URL = {https://www.documentation.ird.fr/hor/fdi:010017844},
}