@article{fdi:010017166,
  title = {{R}andomised study of the possible adjuvant effect of {BCG} vaccine on the immunogenicity of diphtheria-tetanus-acellular pertussis vaccine in {S}enegalese infants},
  author = {{S}imondon, {F}ran{\c{c}}ois and {P}r{\'e}ziosi, {M}.{P}. and {P}inchinat, {S}. and {Y}am, {A}. and {C}habirand, {L}. and {W}assilak, {S}. and {P}ines, {E}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {S}alomon, {H}. and {H}offenbach, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}ollowing a study in {S}enegal (1990-1995) in which the relative efficacy of a diphtheria-tetanus-acellular pertussis vaccine ({DT}a{P}) was compared with that of a diphtheria-tetanus-whole-cell pertussis vaccine in children given a simultaneous injection of {B}acille {C}almette-{G}u{\'e}rin ({BCG}) vaccine, this subsequent study was conducted to evaluate the possible adjuvant effect of the {BCG} vaccine on acellular pertussis vaccine components. {A} second objective was to compare the immunogenicity of these components when administered in accordance with a 2-4-6-month (spaced) schedule or an accelerated 2-3-4-month schedule. {I}n all, 390 healthy {S}enegalese infants were randomly divided into three groups of 130 infants. {A}ntibodies to acellular pertussis components were measured in serum samples obtained within 2 days of the first {DT}a{P} dose and 1 month after the third dose. {BCG} vaccine, given simultaneously with the {DT}a{P} vaccine, did not influence the immunogenicity of the acellular pertussis vaccine components when compared with separate adminstration of the two vaccines. {I}nfants immunised according to a 2-4-6-month schedule had a significantly higher immune response than those immunised according to a 2-3-4-month schedule with respect to the response to pertussis toxoid assessed by seroneutralisation on {C}hinese hamster ovary cells ({P} is less than 0.0001). {T}hese results suggest that {BCG} and {DT}a{P} vaccines can be given simultaneously without interference or enhancement and that more optimal immunogenicity is achieved with an extended than with an accelerated schedule. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SANTE} {PUBLIQUE} ; {VACCINATION} ; {IMMUNOLOGIE} ; {PREVENTION} {SANITAIRE} ; {ETUDE} {DE} {CAS} ; {IMMUNITE} ; {PREVALENCE} ; {PALUDISME} ; {ENFANT} ; {SEROLOGIE} ; {VACCIN} {BCG} ; {VACCIN} {DTAP} ; {VACCIN} {DIPTERIE} {TETANOS} {ACELLULAIRE} {COQUELUCHE} ; {SENEGAL} ; {NIAKHAR}},
  booktitle = {},
  journal = {{E}uropean {J}ournal of {C}linical {M}icrobiology and {I}nfectious {D}iseases},
  volume = {18},
  numero = {},
  pages = {23--29},
  ISSN = {0934-9723},
  year = {1999},
  URL = {https://www.documentation.ird.fr/hor/fdi:010017166},
}