HLA-A, -B, -C, -DR, -DQ typing in a population group of Senegal : distribution of HLA antigens and HLA-DRB1*13 and DRB1*11 subtyping by PCR using sequence-specific primers

HLA-A, -B, -C, -DR, -DQ typing in a population group of Senegal : distribution of HLA antigens and HLA-DRB1*13 and DRB1*11 subtyping by PCR using sequence-specific primers Dieye A. auteur aut IRD Diaw M.L. auteur aut IRD Rogier C. auteur aut IRD Trape Jean-François auteur aut IRD Sarthou J. L. auteur aut IRD text journalArticle eng text/pdf reformatted digital access One-hundred-and sixteen Senegalese Serere were typed for HLA antigens and compared with other ethnic groups in Gambia. We did not find significant differences (Fisher's exact test; P0.01) in the HLA antigens distribution between the Serere and Mandinka groups in Senegal and the Serere, Mandinka and Wolof in The Gambia. The most common HLA haplotypes found (P0.01; Chi square with Yates' correction) were: A1, B8; A2, B51; A32, B44; A33, B58; A2, Cw2; A2, Cw4; A33, Cw3; A2, DR17; A10, DR10; B35, Cw4; B53, Cw6; B57, Cw3; B65, Cw8; B50, DR15; B52, DR4; Cw2, DR17; DR7, DQ2; DR18, DQ4. The HLA-DRB1*13 and DRB1*11 alleles were subtyped by PCR-SSP and the frequencies of these alleles in the studied population given. HLA-DRB1*1304 and DRB1102 were the most common alleles found respectively 15.0 and 18.5% specialized EPIDEMIOLOGIE PALUDISME ANEMIE ANTIGENE IMMUNOLOGIE GROUPE ETHNIQUE GENETIQUE DE POPULATION TYPOLOGIE SYSTEME HLA FREQUENCE ALLELIQUE TECHNIQUE PCR SENEGAL GAMBIE 052ANOPAL03 Tissue Antigens 47 194-199 1996 0001-2815 https://www.documentation.ird.fr/hor/fdi:010016493 10.1111/j.1399-0039.1996.tb02540.x 0001-2815 [F B010016493] https://www.documentation.ird.fr/hor/fdi:010016493 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_53-54/010016493.pdf IRD - Base Horizon / Pleins textes 1998-12-30 2025-05-23 fdi:010016493 fre