@article{fdi:010016144,
  title = {{R}esponse to conjugate {H}aemophilus influenzae {B} vaccine among infants in {N}iamey, {N}iger},
  author = {{C}ampagne, {G}. and {G}arba, {A}. and {S}chuchat, {A}. and {B}oulanger, {D}enis and {P}likaytis, {B}.{D}. and {O}usseini, {M}. and {C}hippaux, {J}ean-{P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{D}espite near elimination of #{H}aemophilus influenzae$ b ({H}ib) meningitis from several industrialized countries following introduction of conjugate {H}ib vaccines into infant immunization schedules, {H}ib remains a major cause of meningitis and pneumonia in resource-poor countries. {I}n {N}iger, {H}ib causes nearly 200 cases of meningitis per 100,000 children < one year of age, and > 40% of cases are fatal. {W}e evaluated the immunogenicity of {H}ib polysaccharide-tetanus toxoid conjugate vaccine ({PRP}-{T}) administered in the same syringe as diphtheria-tetanus-pertussis ({DTP}) vaccine among infants in {N}iger. {I}nfants were randomized into group 1 ({PRP}-{T} at six, 10, and 14 weeks), group 2 ({PRP}-{T} at 10 and 14 weeks), or a control group (meningococcal {A}/{C} polysaccharide vaccine). {B}y 14 weeks of age, all subjects in groups 1 and 2 had 0.15 or more microg/ml of anti-{PRP} antibody, and 82% versus 76% had 1.0 or more microg/ml of antibody ({P} = not significant). {B}y nine months of age the proportion of infants with 0.15 or more and 1.0 or more microg/ml was group 1 = 97% and 76% ; group 2 = 93% and 67% ; controls = 10% and 2.6%. {F}our weeks after the first, second, and third doses of {PRP}-{T}, infants in group 1 showed geometric mean titers ({GMT}s) of 0.19, 3.97, and 6.09 microg/ml while infants in group 2 had {GMT}s of 2.40 and 4.41 microg/ml four weeks after the delayed first and second doses. {B}oth {PRP}-{T} groups had significantly higher {GMT}s at 18 weeks and nine months of age than infants in the control group. {T}he {H}ib {PRP}-{T} vaccine was immunogenic in infants in {N}iger. {T}he strong response after {PRP}-{T} was initiated one month after the first {DTP} vaccination may reflect carrier priming. {T}wo dose schedules of {PRP}-{T} should be given serious consideration, particularly if their reduced cost permits vaccine introduction that would be otherwise unaffordable. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SANTE} {PUBLIQUE} ; {VACCINATION} ; {NOURRISSON} ; {ANTICORPS} ; {DOSAGE} ; {EFFICACITE} ; {ANALYSE} {STATISTIQUE} ; {MENINGITE} ; {NIGER} ; {NIAMEY}},
  booktitle = {},
  journal = {},
  volume = {59},
  numero = {5},
  pages = {837--842},
  ISSN = {0002-9637},
  year = {1998},
  URL = {https://www.documentation.ird.fr/hor/fdi:010016144},
}