@article{fdi:010015513,
  title = {{I}sotopic analysis of maternally transmitted {P}lasmodium falciparum specific antibodies in {C}ameroon, and relationship with risk of {P}. falciparum infection},
  author = {{D}eloron, {P}hilippe and {D}ubois, {B}. and {L}e {H}esran, {J}ean-{Y}ves and {R}iche, {D}. and {F}ievet, {N}adine and {C}ornet, {M}. and {R}ingwald, {P}ascal and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n malaria-endemic areas, infants are relatively protected against malaria infection. {S}uch protection is though to be related principally to the transplacental transfer of maternal antibodies. {W}e measured total and #{P}lasmodium falciparum$-specific {I}g{G} (including subclasses), {I}g{M}, and {I}g{E} antibodies in 154 paired maternal-cord serum samples from an area of meso- to hyperendemic malaria in {S}outh {C}ameroon. {A}mong peripheral mother blood samples, total {I}g{G} and {I}g{M} were detected in all samples, {I}g{E} in all but two. #{P}lasmodium falciparum$-specific {I}g{G} were detected in all serum samples, {I}g{M} and {I}g{E} in > 75% of samples. {T}he prevalence rates of anti-#{P}. falciparum$ {I}g{G} subclasses varied from 75% to 97%. {W}ith the exception of #{P}. falciparum$-specific {I}g{G}, all antibody class and subclass levels were lower in cord blood transferred to the offspring more often and more efficiently than {I}g{G}2 and {I}g{G}4. {T}he detection of total and #{P}. falciparum$-specific {I}g{M} and {I}g{E} in some cord serum samples demonstrated that fetuses can mount humoral response against malaria parasites. {W}e also determined whether transplacentally acquired antibodies protect against malaria infection by relating the antibody levels at birth to the risk of acquiring #{P}. falciparum$ infection during the first 6 months of life. {A}mong various classes and subclasses of #{P}. falciparum$-specific antibodies, only {I}g{G}2 were related to a decrease in the risk of acquiring a #{P}. falciparum$ peripheral blood infection from birth to 6 months of age. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {ENDEMIE} ; {EPIDEMIOLOGIE} ; {IMMUNOLOGIE} ; {RESISTANCE} ; {ANTICORPS} ; {TRANSMISSION} ; {GROSSESSE} ; {NOURRISSON} ; {PREVALENCE} ; {MORBIDITE} ; {PALUDISME} {PLACENTAIRE} ; {CAMEROUN} {SUD} ; {EBOLOWA} ; {YAOUNDE} {REGION}},
  booktitle = {},
  journal = {{C}linical and {E}xperimental {I}mmunology},
  volume = {110},
  numero = {},
  pages = {212--218},
  ISSN = {0009-9104},
  year = {1997},
  URL = {https://www.documentation.ird.fr/hor/fdi:010015513},
}