%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Chippaux, Jean-Philippe
%A Bouchité, Bernard
%A Boussinesq, Michel
%A Ranque, Sophie
%A Baldet, Thierry
%A Demanou, M.
%T Impact of repeated large scale ivermectin treatments on the transmission of Loa loa
%D 1998
%L fdi:010014873
%G ENG
%J Transactions of the Royal Society of Tropical Medicine and Hygiene
%@ 0035-9203
%K LOASE ; ENDEMIE ; TRAITEMENT MEDICAL ; VECTEUR ; DYNAMIQUE DE POPULATION ; INFECTION ; PREVALENCE
%K IVERMECTINE ; CHIMIOTHERAPIE DE MASSE
%K CAMEROUN CENTRE
%K NGAT
%N 4
%P 454-458
%R 10.1016/S0035-9203(98)91091-4
%U https://www.documentation.ird.fr/hor/fdi:010014873
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_51-52/010014873.pdf
%V 92
%W Horizon (IRD)
%X We have studied the impact of large-scale treatment with ivermectin on the transmission of loiasis in a forest village in south Cameroon where loiasis was highly endemic, with a prevalence of 30%. After one year of parasitological and entomological surveillance without treatment, all consenting residents aged > 5 years received ivermectin 200 microg/kg every 3 months. For ethical reasons, treatment was interrupted after 2 years, but parasitological and entomological surveillance continued for 18 months after the end of treatment. The prevalence of loiasis was reduced to < 10% and the mean microfilaraemia decreased by 90% in 2 years. The prevalence and average intensity of infection remained stable during the 18 months after treatment ended. Two vector species were identified, #Chrysops dimidiata$ (representing about 90% of the fly population) and #C. silacea$. The infection rate (all stages) in #Chrysops$ decreased by 75% and the infective rate (percentage of #Chrysops$ harbouring third-stage larvae of #Loa loa$ in the head) decreased by 85% in #C. dimidiata$ and became zero in #C. silacea$. After the end of treatment, the infection and infective rates increased gradually. Large-scale treatment seemed an efficient method for the control of #L. loa$ transmission provided high drug coverage was achieved. Nevertheless, because of the high risk of adverse effects when using the current microfilaricidal drugs, such a strategy remains unacceptable. (Résumé d'auteur)
%$ 052MALTRA05