@article{fdi:010014873,
  title = {{I}mpact of repeated large scale ivermectin treatments on the transmission of {L}oa loa},
  author = {{C}hippaux, {J}ean-{P}hilippe and {B}ouchit{\'e}, {B}ernard and {B}oussinesq, {M}ichel and {R}anque, {S}ophie and {B}aldet, {T}hierry and {D}emanou, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e have studied the impact of large-scale treatment with ivermectin on the transmission of loiasis in a forest village in south {C}ameroon where loiasis was highly endemic, with a prevalence of 30%. {A}fter one year of parasitological and entomological surveillance without treatment, all consenting residents aged > 5 years received ivermectin 200 microg/kg every 3 months. {F}or ethical reasons, treatment was interrupted after 2 years, but parasitological and entomological surveillance continued for 18 months after the end of treatment. {T}he prevalence of loiasis was reduced to < 10% and the mean microfilaraemia decreased by 90% in 2 years. {T}he prevalence and average intensity of infection remained stable during the 18 months after treatment ended. {T}wo vector species were identified, #{C}hrysops dimidiata$ (representing about 90% of the fly population) and #{C}. silacea$. {T}he infection rate (all stages) in #{C}hrysops$ decreased by 75% and the infective rate (percentage of #{C}hrysops$ harbouring third-stage larvae of #{L}oa loa$ in the head) decreased by 85% in #{C}. dimidiata$ and became zero in #{C}. silacea$. {A}fter the end of treatment, the infection and infective rates increased gradually. {L}arge-scale treatment seemed an efficient method for the control of #{L}. loa$ transmission provided high drug coverage was achieved. {N}evertheless, because of the high risk of adverse effects when using the current microfilaricidal drugs, such a strategy remains unacceptable. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{LOASE} ; {ENDEMIE} ; {TRAITEMENT} {MEDICAL} ; {VECTEUR} ; {DYNAMIQUE} {DE} {POPULATION} ; {INFECTION} ; {PREVALENCE} ; {IVERMECTINE} ; {CHIMIOTHERAPIE} {DE} {MASSE} ; {CAMEROUN} {CENTRE} ; {NGAT}},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {92},
  numero = {4},
  pages = {454--458},
  ISSN = {0035-9203},
  year = {1998},
  DOI = {10.1016/{S}0035-9203(98)91091-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010014873},
}