@article{fdi:010013692,
  title = {{T}he impact of {M}ectizan on the transmission of onchocerciasis},
  author = {{B}oatin, {B}.{A}. and {H}ougard, {J}ean-{M}arc and {A}lley, {E}.{S}. and {A}kpoboua, {L}.{K}.{B}. and {Y}am{\'e}ogo, {L}. and {D}emb{\'e}l{\'e}, {N}. and {S}{\'e}k{\'e}t{\'e}li, {A}. and {D}adzie, {K}.{Y}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}or many years there was no suitable drug available for the control of onchocerciasis. {T}he advent of {M}ectizan (ivermectin, {MSD} ; an effective microfilaricide), its registration in {O}ctober 1987 for the treatment of human onchocerciasis, and its suitability for large-scale application were major break-throughs in the control of human onchocerciasis via chemotherapy. {S}everal studies, both fly-feeding experiments and community trials, have established that {M}ectizan treatment causes a significant reduction in the transmission of infection. {A}lthough long-term treatment in some isolated foci (such as occur in the {N}ew {W}orld and in some hypo- and meso-endemic areas elsewhere) appears to interrupt transmission, more prolonged treatement is required to prove if transmission can be stopped. {A}dvantage could be taken of the significant impact of {M}ectizan on transmission by giving treatement while or just before transmission by blackflies is most intense. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{ONCHOCERCOSE} ; {VECTEUR} ; {VARIATION} {SAISONNIERE} ; {TRANSMISSION} ; {EPIDEMIOLOGIE} ; {CHIMIOTHERAPIE} {DE} {MASSE} ; {IVERMECTINE} ; {MECTIZAN} ; {AFRIQUE} {DE} {L}'{OUEST} ; {GUATEMALA}},
  booktitle = {{M}ectizan and onchocerciasis : a decade of accomplishment and prospects for the future : the evolution of a drug into a development concept},
  journal = {{A}nnals of {T}ropical {M}edicine and {P}arasitology},
  volume = {92},
  numero = {{S}uppl. 1},
  pages = {47--60},
  ISSN = {0003-4983},
  year = {1998},
  DOI = {10.1080/00034989859555},
  URL = {https://www.documentation.ird.fr/hor/fdi:010013692},
}