@article{fdi:010013181,
  title = {{M}olecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector {A}nopheles gambiae s.s.},
  author = {{M}artinez-{T}orres, {D}. and {C}handre, {F}abrice and {W}illiamson, {M}.{S}. and {D}arriet, {F}r{\'e}d{\'e}ric and {B}erg{\'e}, {J}.{B}. and {D}evonshire, {A}.{L}. and {G}uillet, {P}ierre and {P}asteur, {N}. and {P}auron, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}yrethroid-impregnated bednets are playing an increasing role for combating malaria, especially in stable malaria areas. {M}ore than 90% of the current annual malaria incidence (c. 500 million clinical cases with up to 2 million deaths) is in {A}frica where the major vector is #{A}nopheles gambiae$ s.s. {A}s pyrethroid resistance has been reported in this mosquito, reliable and simple techniques are urgently needed to characterize and monitor this resistance in the field. {I}n insects, an important mechanism of pyrethroid resistance is due to a modification of the voltage-gated sodium channel protein recently shown to be associated with mutations of the para-type sodium channel gene. {W}e demonstrate here that one of these mutations is present in certain strains of pyrethroid resistant #{A}. gambiae$ s.s. and describe a {PCR}-based diagnostic test allowing its detection in the genome of single mosquitoes. {U}sing this test, we found this mutation in six out of seven field samples from {W}est {A}frica, its frequency being closely correlated with survival to pyrethroid exposure. {T}his diagnostic test should bring major improvement for field monitoring of pyrethroid resistance, within the framework of malaria control programmes. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {MOUSTIQUE} ; {RESISTANCE} ; {DIAGNOSTIC} ; {VECTEUR} ; {MOUSTIQUAIRE} {IMPREGNEE} ; {PYRETHROIDES} {RESISTANCE} ; {LUTTE} {ANTIVECTORIELLE} ; {AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{I}nsect {M}olecular {B}iology},
  volume = {7},
  numero = {2},
  pages = {179--184},
  ISSN = {0962-1075},
  year = {1998},
  DOI = {10.1046/j.1365-2583.1998.72062.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010013181},
}