%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Breton, B.
%A Diagne, M.
%A Wanji, S.
%A Bougnoux, M.E.
%A Chandre, Fabrice
%A Maréchal, P.
%A Petit, G.
%A Vuong, P.N.
%A Bain, O.
%T Ivermectin and moxidectin in two filarial systems : resistance of Monanema martini; inhibition of Litomosoides sigmodontis insemination
%D 1997
%L fdi:010012727
%G ENG
%J Parassitologia
%K FILARIOSE ; SENSIBILITE RESISTANCE ; TRAITEMENT MEDICAL ; ETUDE COMPARATIVE ; HISTOLOGIE
%K IVERMECTINE ; MOXIDECTINE ; MICROFILAIRE ; INHIBITEUR D'INSEMINATION
%P 19-28
%U https://www.documentation.ird.fr/hor/fdi:010012727
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_47-48/010012727.pdf
%V 39
%W Horizon (IRD)
%X Effects of ivermectin and moxidectin were compared on two filarial species : #Monanema martini$ which presents dermal microfilariae and induces #Onchocerca$-like lesions in its natural murid host #Lemniscomys striatus$, and #Litomosoides sigmodontis$ (=#L. carinii$). #M. martini$ microfilariae showed an unusual resistance to ivermectin, in vitro and in vivo ; moxidectin was no more efficient. However, the two drugs used at high concentrations deeply altered the uterine embryogenesis, but had no lethal effect on adult filariae. #L. sigmodontis$ blood microfilariae showed a great susceptibility to moxidectin, similar to that previously described for ivermectin. The two drugs also induced a long term effect because they inhibited the insemination of the female filariae. This result reinforces the observations made by other authors on the human parasite, #Onchocerca volvulus$. (Résumé d'auteur)
%$ 052SIMONC04 ; 052MALTRA05