@article{fdi:010012727,
  title = {{I}vermectin and moxidectin in two filarial systems : resistance of {M}onanema martini; inhibition of {L}itomosoides sigmodontis insemination},
  author = {{B}reton, {B}. and {D}iagne, {M}. and {W}anji, {S}. and {B}ougnoux, {M}.{E}. and {C}handre, {F}abrice and {M}ar{\'e}chal, {P}. and {P}etit, {G}. and {V}uong, {P}.{N}. and {B}ain, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}ffects of ivermectin and moxidectin were compared on two filarial species : #{M}onanema martini$ which presents dermal microfilariae and induces #{O}nchocerca$-like lesions in its natural murid host #{L}emniscomys striatus$, and #{L}itomosoides sigmodontis$ (=#{L}. carinii$). #{M}. martini$ microfilariae showed an unusual resistance to ivermectin, in vitro and in vivo ; moxidectin was no more efficient. {H}owever, the two drugs used at high concentrations deeply altered the uterine embryogenesis, but had no lethal effect on adult filariae. #{L}. sigmodontis$ blood microfilariae showed a great susceptibility to moxidectin, similar to that previously described for ivermectin. {T}he two drugs also induced a long term effect because they inhibited the insemination of the female filariae. {T}his result reinforces the observations made by other authors on the human parasite, #{O}nchocerca volvulus$. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{FILARIOSE} ; {SENSIBILITE} {RESISTANCE} ; {TRAITEMENT} {MEDICAL} ; {ETUDE} {COMPARATIVE} ; {HISTOLOGIE} ; {IVERMECTINE} ; {MOXIDECTINE} ; {MICROFILAIRE} ; {INHIBITEUR} {D}'{INSEMINATION}},
  booktitle = {},
  journal = {{P}arassitologia},
  volume = {39},
  numero = {},
  pages = {19--28},
  year = {1997},
  URL = {https://www.documentation.ird.fr/hor/fdi:010012727},
}