%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Fournet, Alain
%A Ferreira, M.E.
%A Rojas de Arias, A.
%A Torres de Ortiz, S.
%A Inchausti, A.
%A Yaluff, G.
%A Quilhot, W.
%A Fernandez, E.
%A Hidalgo, M.E.
%T Activity of compounds isolated from chilean lichens against experimental cutaneous leishmaniasis
%D 1997
%L fdi:010009663
%G ENG
%J Comparative Biochemistry and Physiology
%@ 0742-8413
%K LEISHMANIOSE ; TRAITEMENT MEDICAL ; EFFICACITE ; ETUDE EXPERIMENTALE ; PLANTE MEDICINALE ; EXTRACTION ; ANIMAL DE LABORATOIRE
%K LICHEN ; ACIDE USNIQUE ; PANNARINE ; CHLOROPANNARINE
%N 1
%P 51-54
%U https://www.documentation.ird.fr/hor/fdi:010009663
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010009663.pdf
%V 116C
%W Horizon (IRD)
%X Three secondary metabolites isolated from Chilean lichens, (+) usnic acid, pannarine and 1'-chloropannarine, were tested against promastigotes forms of three strains of #Leishmania$ ssp. Pannarine and 1'-chloropannarine exhibited in vitro activity at 50 microg/ml and (+) usnic acid at 25 microg/ml. BALB/c mice infected with #Leishmania amazonensis$ were treated 4 weeks post-infection with (+) usnic acid by subcutaneous or oral routes for 15 days at 25 mg/kg or by five intralesional injections at interval of 4 days at 25 mg/kg of body weight. The reference drug, N-methylglucamine antimonate (Glucantime), was administered by subcutaneous injections (regimens of 28 mg of pentavalent antimony) for 15 days. The subcutaneous and oral treatments with (+) usnic did not produce any effect, but by intralesional administration we observed a significant effect that reduced by 43.34% the weight lesions and by 72.28% the parasites loads in infected footpads. (Résumé d'auteur)
%$ 052PHLEIS03 ; 076PLAMED03