Activity of compounds isolated from chilean lichens against experimental cutaneous leishmaniasis /Fournet, Alain Ferreira, M.E. Rojas de Arias, A. Torres de Ortiz, S. Inchausti, A. Yaluff, G. Quilhot, W. Fernandez, E. Hidalgo, M.E. LEISHMANIOSE TRAITEMENT MEDICAL EFFICACITE ETUDE EXPERIMENTALE PLANTE MEDICINALE EXTRACTION ANIMAL DE LABORATOIRE LICHEN ACIDE USNIQUE PANNARINE CHLOROPANNARINE Three secondary metabolites isolated from Chilean lichens, (+) usnic acid, pannarine and 1'-chloropannarine, were tested against promastigotes forms of three strains of Leishmania ssp. Pannarine and 1'-chloropannarine exhibited in vitro activity at 50 microg/ml and (+) usnic acid at 25 microg/ml. BALB/c mice infected with Leishmania amazonensis were treated 4 weeks post-infection with (+) usnic acid by subcutaneous or oral routes for 15 days at 25 mg/kg or by five intralesional injections at interval of 4 days at 25 mg/kg of body weight. The reference drug, N-methylglucamine antimonate (Glucantime), was administered by subcutaneous injections (regimens of 28 mg of pentavalent antimony) for 15 days. The subcutaneous and oral treatments with (+) usnic did not produce any effect, but by intralesional administration we observed a significant effect that reduced by 43.34% the weight lesions and by 72.28% the parasites loads in infected footpads. (Résumé d'auteur) 1997 text https://www.documentation.ird.fr/hor/fdi:010009663 fdi:010009663 Fournet Alain, Ferreira M.E., Rojas de Arias A., Torres de Ortiz S., Inchausti A., Yaluff G., Quilhot W., Fernandez E., Hidalgo M.E.. Activity of compounds isolated from chilean lichens against experimental cutaneous leishmaniasis. 1997, 116C (1), 51-54 EN