@article{fdi:010009663,
  title = {{A}ctivity of compounds isolated from chilean lichens against experimental cutaneous leishmaniasis},
  author = {{F}ournet, {A}lain and {F}erreira, {M}.{E}. and {R}ojas de {A}rias, {A}. and {T}orres de {O}rtiz, {S}. and {I}nchausti, {A}. and {Y}aluff, {G}. and {Q}uilhot, {W}. and {F}ernandez, {E}. and {H}idalgo, {M}.{E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}hree secondary metabolites isolated from {C}hilean lichens, (+) usnic acid, pannarine and 1'-chloropannarine, were tested against promastigotes forms of three strains of #{L}eishmania$ ssp. {P}annarine and 1'-chloropannarine exhibited in vitro activity at 50 microg/ml and (+) usnic acid at 25 microg/ml. {BALB}/c mice infected with #{L}eishmania amazonensis$ were treated 4 weeks post-infection with (+) usnic acid by subcutaneous or oral routes for 15 days at 25 mg/kg or by five intralesional injections at interval of 4 days at 25 mg/kg of body weight. {T}he reference drug, {N}-methylglucamine antimonate ({G}lucantime), was administered by subcutaneous injections (regimens of 28 mg of pentavalent antimony) for 15 days. {T}he subcutaneous and oral treatments with (+) usnic did not produce any effect, but by intralesional administration we observed a significant effect that reduced by 43.34% the weight lesions and by 72.28% the parasites loads in infected footpads. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{LEISHMANIOSE} ; {TRAITEMENT} {MEDICAL} ; {EFFICACITE} ; {ETUDE} {EXPERIMENTALE} ; {PLANTE} {MEDICINALE} ; {EXTRACTION} ; {ANIMAL} {DE} {LABORATOIRE} ; {LICHEN} ; {ACIDE} {USNIQUE} ; {PANNARINE} ; {CHLOROPANNARINE}},
  booktitle = {},
  journal = {{C}omparative {B}iochemistry and {P}hysiology},
  volume = {116{C}},
  numero = {1},
  pages = {51--54},
  ISSN = {0742-8413},
  year = {1997},
  URL = {https://www.documentation.ird.fr/hor/fdi:010009663},
}