@article{fdi:010008182,
  title = {{P}resence of multiple non-{B} subtypes and divergent subtype {B} strains of {HIV}-1 in individuals infected after overseas deployment},
  author = {{L}asky, {M}ariama and {P}erret, {J}.{L}. and {P}eeters, {M}artine and {B}ibollet-{R}uche, {F}r{\'e}d{\'e}ric and {L}iegeois, {F}lorian and {P}atrel, {D}elphine and {M}olinier, {S}. and {G}ras, {C}. and {D}elaporte, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective : to identify the genetic subtypes and characteristics of {HIV}-1 strains from individuals infected after overseas deployment. {S}ixty-one {HIV}-1-positive individuals detected between 1986 and 1995 in the {F}rench army were included in the study. {F}or each patient, the year and country of {HIV} infection are known. {G}enetic subtypes of {HIV}-1 were determined using the heteroduplex mobility assay ({HMA}) using {ED}5/{ED}12 as outer and {ES}7/{ES}8 as inner primers. {S}trains were further characterized by sequencing and phylogenetic analysis of the {C}2-{V}3 region. {T}he aminoacid sequences corresponding to the {V}3 region were aligned on the basis of the subtyping results and were then compared to the consensus {V}3 sequences of the corresponding subtypes. {A}mong the 61 patients studied, nine became infected in {F}rance, and 52 were {HIV}-negative before overseas deployment but {HIV}-positive at their return. {T}he majority (n = 43) deployed in {A}frica and a limited number of patients deployed in {A}sia ({C}ambodia, n = 5) or {S}outh {A}merica ({G}uyana, n = 4). {T}he nine individuals who were not deployed overseas were all infected with subtype {B} strains. {T}he majority the other patients were infected with non-{B} strains ; eight subtype {A}, 20 subtype {B}, 16 subtype {C}, one subtype {D}, six subtype {E} and one subtype {F}. {F}ive of the six subtype {E} strains were contracted in {C}ambodia and one in {D}jibouti, and all subtype {C} strains were from {D}jibouti. {P}hylogenetic analysis revealed a large diversity among the different strains introduced into {F}rance. {A}nalysis of the aminoacid sequences of the {V}3 loop revealed the introduction of uncommon {V}3-loop patterns. {I}n the group of {HIV}-1-infected individuals that we studied and who were deployed overseas, 63.4% were infected with non-{B} strains. {I}n addition the subtype {A}, {B}, and {C} viruses in this population were very heterogeneous. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SIDA} ; {VIROSE} ; {AGENT} {PATHOGENE} ; {POLYMORPHISME} {GENETIQUE} ; {IDENTIFICATION} ; {EPIDEMIOLOGIE} ; {PHYLOGENIE} ; {VIRUS} {HIV}-1 ; {PCR}.{REACTION} {DE} {POLYMERISATION} {EN} {CHAINE} ; {FRANCE} ; {ASIE} ; {AFRIQUE}},
  booktitle = {},
  journal = {{AIDS}},
  volume = {11},
  numero = {1},
  pages = {43--51},
  ISSN = {0269-9370},
  year = {1997},
  DOI = {10.1097/00002030-199701000-00007},
  URL = {https://www.documentation.ird.fr/hor/fdi:010008182},
}