@article{fdi:010007534,
  title = {{I}n vitro activity of antimalarials against clinical isolates of {P}lasmodium falciparum in {Y}aounde, {C}ameroon},
  author = {{R}ingwald, {P}ascal and {B}ickii, {J}. and {B}asco, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he in vitro activity of nine antimalarials was determined against 119 fresh clinical isolates of #{P}lasmodium falciparum$ obtained from symptomatic indigenous patients in {Y}aounde, {C}ameroun, using the isotopic semimicrotest. {S}eventy-four parasites were resistant to chloroquine (mean 50% inhibitory concentration [{IC}50] 337 n{M}) ; 45 were chloroquine-sensitive (mean {IC}50 35.6 n{M}). {T}wenty-five of 58 chloroquine-resistant parasites were resistant to monodesethylamodiaquine, the biologically active metabolite of amodiaquine. {N}one of the chloroquine-sensitive isolates was resistant to monodesethylamodiaquine ({IC}50 17.3 n{M}). {P}yronaridine, quinine, mefloquine, halofantrine, and artemether were highly active against the chloroquine-sensitive and the chloroquine-resistant isolates. {O}f the 43 isolates tested, 25 were sensitive to both pyrimethamine and cycloguanil, the biologically active metabolite of proguanil. {T}he in vitro responses of chloroquine and monodesethylamodiaquine, chloroquine and quinine, quinine and mefloquine, mefloquine and halofantrine, artemether and mefloquine or halofantrine, and pyrimethamine and cycloguanil were significantly correlated. {T}he present study suggests that chloroquine resistance is highly prevalent in vitro in {Y}aounde and that the alternative drugs are generally highly active against the chloroquine-resistant parasites. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {AGENT} {PATHOGENE} ; {SENSIBILITE} {RESISTANCE} ; {MEDICAMENT} ; {EFFICACITE} ; {CHLOROQUINE} ; {MONODESETHYLAMODIAQUINE} ; {PYRONARIDINE} ; {QUININE} ; {MEFLOQUINE} ; {HALOFANTRINE} ; {ARTEMETHER} ; {CYCLOGUANIL} ; {PYRIMETHAMINE} ; {SCHEMA} {THERAPEUTIQUE} ; {CAMEROUN} ; {YAOUNDE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {55},
  numero = {3},
  pages = {254--258},
  ISSN = {0002-9637},
  year = {1996},
  URL = {https://www.documentation.ird.fr/hor/fdi:010007534},
}