%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Nyambi, P.N.
%A Ville, Y.
%A Louwagie, J.
%A Bedjabaga, I.
%A Glowaczower, E.
%A Peeters, Martine
%A Kerouedan, D.
%A Dazza, M.C.
%A Larouzé, B.
%A Van der Groen, G.
%A Delaporte, Eric
%T Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I/II) in Gabon : a prospective follow-up of 4 years
%D 1996
%L fdi:010006219
%G ENG
%J Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
%@ 0894-9255
%K SIDA ; GROSSESSE ; EPIDEMIOLOGIE ; TRANSMISSION ; FOETUS ; NOURRISSON ; SEROLOGIE ; ADN
%K LEUCEMIE ; LYMPHOME ; VIRUS HTLV-1 ; VIRUS HTLV-2 ; PCR. POLYMERASE CHAIN REACTION
%K GABON
%N 2
%P 187-192
%U https://www.documentation.ird.fr/hor/fdi:010006219
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010006219.pdf
%V 12
%W Horizon (IRD)
%X For 4 years, we determined the mode and risk of mother-to-child transmission of HTLV-I in a prospective cohort of 34 children born to seropositive mothers in Franceville, Gabon. We also determined the prevalence of antibodies to HTLV-I/II in siblings born to seropositive mothers. Antibodies to HTLV-I/II were detected by Western blot, and the proviral DNA was detected by the polymerase chain reaction (PCR). The risk of seroconversion to anti-HTLV-I for the 4 years of follow-yp was 17.5 %. Anti-HTLV-I/II and proviral DNA were only detected after age 18 months. We observed a seroprevalence rate of 15 % among the siblings born to HTLV-I/II seropositive mothers. Furthermore, we report a case of mother-to-child transmission of HTLV-II infection in a population of HTLV-II-infected pregnant women that is emerging in Gabon. The lack of detection of HTLV-I/II proviral DNA in cord blood and amniotic fluid and, furthermore, the late seroconversion observed in the children indirectly indicate that mother-to-child transmission occured postnatally, probably through breast milk. (Résumé d'auteur)
%$ 052MALTRA03