@article{fdi:010006205,
  title = {{P}attern of immunoglobulin isotype response to {P}lasmodium falciparum blood-stage antigens in individuals living in a holoendemic area of {S}enegal ({D}ielmo, {W}est {A}frica)},
  author = {{A}ribot, {G}. and {R}ogier, {C}. and {S}arthou, {J}.{L}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {T}oure {B}alde, {A}. and {D}ruilhe, {P}. and {R}oussilhon, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}hree cross sectional studies were conducted in a representative cohort of individuals living continuously in an area holoendemic for malaria in {S}enegal. {P}lasma from 145 children and adults were tested. {T}he pattern of antimalarial immunoglobulin class ({I}g{M} and {I}g{G}) and subclass ({I}g{G}1 and {I}g{G}4) antibody distribution was determined by enzyme-linked immunosorbent assay using a crude blood-stage antigen of #{P}lasmodium falciparum$-infected red blood cells. {A}dults had higher levels of specific antibodies than children, and {I}g{M}, {I}g{G}2 and {I}g{G}3 accounted for the highest difference (2.9, 6.5 and 4.5 times, respectively). {D}ifferences in antibody levels were significant for {I}g{G}1 to {I}g{G}4 between the lowest and the highest transmission season. {N}o particular isotype distribution pattern could be found associated with any given parasitemia level. {T}he relationship between the optical density ({OD}) values of each isotype and the risk of clinical malaria attack was tested using a {P}oisson regression model. {O}nly the {I}g{G}3 {OD} increases were found associated with a significantly reduced risk of malaria attack. {T}hese seroepidemiologic data suggest that whereas the total {I}g{G}-specific activity is not indicative of any given level of protection against malaria, the level of {I}g{G}3 was significantly associated with the relative susceptibility to clinical #{P}lasmodium falciparum$ malaria attacks. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {EPIDEMIOLOGIE} ; {IMMUNOLOGIE} ; {SEROLOGIE} ; {ANTIGENE} ; {AGENT} {PATHOGENE} ; {ANTICORPS} ; {ISOTYPE} ; {SENEGAL} ; {DIELMO}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {54},
  numero = {5},
  pages = {449--457},
  ISSN = {0002-9637},
  year = {1996},
  URL = {https://www.documentation.ird.fr/hor/fdi:010006205},
}