@article{PAR00026654, title = {{M}echanisms of intrinsic postzygotic isolation : from traditional genic and chromosomal views to genomic and epigenetic perspectives}, author = {{R}eifová, {R}. and {A}ment-{V}elásquez, {S}. {L}. and {B}ourgeois, {Y}ann and {C}oughlan, {J}. and {K}ulmuni, {J}. and {L}ipinska, {A}. {P}. and {O}kude, {G}. and {S}tevison, {L}. and {Y}oshida, {K}. and {K}itano, {J}.}, editor = {}, language = {{ENG}}, abstract = {{I}ntrinsic postzygotic isolation typically appears as reduced viability or fertility of interspecific hybrids caused by genetic incompatibilities between diverged parental genomes. {D}obzhansky-{M}uller interactions among individual genes, and chromosomal rearrangements causing problems with chromosome synapsis and recombination in meiosis, have both long been considered as major mechanisms behind intrinsic postzygotic isolation. {R}ecent research has, however, suggested that the genetic basis of intrinsic postzygotic isolation can be more complex and involves, for example, overall divergence of the {DNA} sequence or epigenetic changes. {H}ere, we review the mechanisms of intrinsic postzygotic isolation from genic, chromosomal, genomic, and epigenetic perspectives across diverse taxa. {W}e provide empirical evidence for these mechanisms, discuss their importance in the speciation process, and highlight questions that remain unanswered.}, keywords = {}, booktitle = {}, journal = {{C}old {S}pring {H}arbor {P}erspectives in {B}iology}, volume = {15}, numero = {10}, pages = {a041607 [ p.]}, ISSN = {1943-0264}, year = {2023}, DOI = {10.1101/cshperspect.a041607}, URL = {https://www.documentation.ird.fr/hor/{PAR}00026654}, }