@article{PAR00026105,
  title = {{C}limate change and vector-borne diseases : a multi-omics approach of temperature-induced changes in the mosquito},
  author = {{B}ellone, {R}. and {L}echat, {P}. and {M}ousson, {L}. and {G}ilbart, {V}. and {P}iorkowski, {G}. and {B}ohers, {C}. and {M}erits, {A}. and {K}ornobis, {E}. and {R}eveillaud, {J}. and {P}aupy, {C}hristophe and {V}azeille, {M}. and {M}artinet, {J}. {P}. and {M}adec, {Y}. and {D}e {L}amballerie, {X}. and {D}auga, {C}. and {F}ailloux, {A}. {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {C}limate change and globalization contribute to the expansion of mosquito vectors and their associated pathogens. {L}ong spared, temperate regions have had to deal with the emergence of arboviruses traditionally confined to tropical regions. {C}hikungunya virus ({CHIKV}) was reported for the first time in {E}urope in 2007, causing a localized outbreak in {I}taly, which then recurred repeatedly over the years in other {E}uropean localities. {T}his raises the question of climate effects, particularly temperature, on the dynamics of vector-borne viruses. {T}he objective of this study is to improve the understanding of the molecular mechanisms set up in the vector in response to temperature. {M}ethods {W}e combine three complementary approaches by examining {A}edes albopictus mosquito gene expression (transcriptomics), bacterial flora (metagenomics) and {CHIKV} evolutionary dynamics (genomics) induced by viral infection and temperature changes. {R}esults {W}e show that temperature alters profoundly mosquito gene expression, bacterial microbiome and viral population diversity. {W}e observe that (i) {CHIKV} infection upregulated most genes (mainly in immune and stress-related pathways) at 20 degrees {C} but not at 28 degrees {C}, (ii) {CHIKV} infection significantly increased the abundance of {E}nterobacteriaceae {S}erratia marcescens at 28 degrees {C} and (iii) {CHIKV} evolutionary dynamics were different according to temperature. {C}onclusion {T}he substantial changes detected in the vectorial system (the vector and its bacterial microbiota, and the arbovirus) lead to temperature-specific adjustments to reach the ultimate goal of arbovirus transmission; at 20 degrees {C} and 28 degrees {C}, the {A}sian tiger mosquito {A}e. albopictus was able to transmit {CHIKV} at the same efficiency. {T}herefore, {CHIKV} is likely to continue its expansion in the northern regions and could become a public health problem in more countries than those already affected in {E}urope.},
  keywords = {{T}emperature ; chikungunya ; {A}edes albopictus},
  booktitle = {},
  journal = {{J}ournal of {T}ravel {M}edicine},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[ p.]},
  ISSN = {1195-1982},
  year = {2023},
  DOI = {10.1093/jtm/taad062},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00026105},
}