@article{PAR00026006,
  title = {{SARS}-{C}o{V}-2 {BW} lineage, a fast-growing {O}micron variant from southeast {M}exico bearing relevant escape mutations},
  author = {{G}arcia-{L}opez, {R}. and {R}ivera-{G}utierrez, {X}. and {R}osales-{R}ivera, {M}. and {Z}arate, {S}. and {M}unoz-{M}edina, {J}. {E}. and {R}oche, {B}enjamin and {H}errera-{E}strella, {A}. and {G}omez-{G}il, {B}. and {S}anchez-{F}lores, {A}. and {T}aboada, {B}. and {A}rias, {C}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}urpose{T}he swift expansion of the {BW}.1 {SARS}-{C}o{V}-2 variant coincided with a rapid increase of {COVID}-19 cases occurring in {S}outheast {M}exico in {O}ctober, 2022, which marked the start of {M}exico's sixth epidemiological wave. {I}n {Y}ucatan, up to 92% (58 of 73) of weekly sequenced genomes between epidemiological week 42 and 47 were identified as either {BW}.1 or its descendant, {BW}.1.1 in the region, during the last trimester of 2022. {I}n the current study, a comprehensive genomic comparison was carried out to characterize the evolutionary history of the {BW} lineage, identifying its origins and its most important mutations.{M}ethods{A}n alignment of all the genomes of the {BW} lineage and its parental {BA}.5.6.2 variant was carried out to identify their mutations. {A} phylogenetic and ancestral sequence reconstruction analysis with geographical inference, as well as a longitudinal analysis of point mutations, were performed to trace back their origin and contrast them with key {RBD} mutations in variant {BQ}.1, one of the fastest-growing lineages to date.{R}esults{O}ur ancestral reconstruction analysis portrayed {M}exico as the most probable origin of the {BW}.1 and {BW}.1.1 variants. {T}wo synonymous substitutions, {T}7666{C} and {C}14599{T}, support their {M}exican origin, whereas other two mutations are specific to {BW}.1: {S}:{N}460{K} and {ORF}1a:{V}627{I}. {T}wo additional substitutions and a deletion are found in its descending subvariant, {BW}.1.1. {M}utations found in the receptor binding domain, {S}:{K}444{T}, {S}:{L}452{R}, {S}:{N}460{K}, and {S}:{F}486{V} in {BW}.1 have been reported to be relevant for immune escape and are also key mutations in the {BQ}.1 lineage.{C}onclusions{BW}.1 appears to have arisen in the {Y}ucatan {P}eninsula in {S}outheast {M}exico sometime around {J}uly 2022 during the fifth {COVID}-19 wave. {I}ts rapid growth may be in part explained by the relevant escape mutations also found in {BQ}.1.},
  keywords = {{G}enomic surveillance ; {SARS}-{C}o{V}-2 variants ; {COVID}-19 ; {O}micron ; {M}utations ; {MEXIQUE}},
  booktitle = {},
  journal = {{I}nfection},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[7 ]},
  ISSN = {0300-8126},
  year = {2023},
  DOI = {10.1007/s15010-023-02034-7},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00026006},
}