@article{PAR00024457,
  title = {{N}atural acquired immunity to malaria antigens among pregnant women with hemoglobin {C} trait},
  author = {{L}opez-{P}erez, {M}. and {V}iwami, {F}. and {D}oritchamou, {J}. and {T}uikue {N}dam, {N}icaise and {H}viid, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}emoglobin {C} is the second most common structural hemoglobinopathy in {A}frica, and carriers have a reduced risk of severe malaria. {H}owever, the effect of {H}b{AC} on the antibody response to malaria antigens in pregnancy has not been studied. {H}ere, we measured {P}f{EMP}1-specific antibodies in plasma samples from 74 {B}eninese pregnant women with either {H}b{AA} or {H}b{AC}. {I}g{G}-mediated inhibition of {VAR}2{CSA}(+) infected erythrocytes adhesion to chondroitin sulfate {A} ({CSA}) was also tested. {P}f{EMP}1-specific {I}g{G} levels to {VAR}2{CSA} were significantly lower in {H}b{AC} women, suggesting less exposure to {VAR}2{CSA}. {I}n contrast, the percentage of {VAR}2{CSA}(+)-infected erythrocytes adhesion to {CSA} was not different between {H}b{AA} and {H}b{AC} women. {M}oreover, {I}g{G} levels to {P}f{EMP}1 variants associated with severe malaria were not significantly different between groups. {T}he findings indicate similar exposure to {P}lasmodium falciparum parasites expressing {P}f{EMP}1 variants causing severe malaria, and justify more comprehensive studies of hemoglobinopathy-related qualitative and quantitative differences in {P}f{EMP}1-specific antibody responses.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {106},
  numero = {3},
  pages = {853--856},
  ISSN = {0002-9637},
  year = {2022},
  DOI = {10.4269/ajtmh.21-1039},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00024457},
}