@article{PAR00023992,
  title = {{T}ransposable element variants and their potential adaptive impact in urban populations of the malaria vector {A}nopheles coluzzii},
  author = {{V}argas-{C}havez, {C}. and {P}endy, {N}. {M}. {L}. and {N}sango, {S}. {E}. and {A}guilera, {L}. and {A}yala, {D}iego and {G}onzalez, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}nopheles coluzzii is one of the primary vectors of human malaria in sub-{S}aharan {A}frica. {R}ecently, it has spread into the main cities of {C}entral {A}frica threatening vector control programs. {T}he adaptation of {A}n. coluzzii to urban environments partly results from an increased tolerance to organic pollution and insecticides. {S}ome of the molecular mechanisms for ecological adaptation are known, but the role of transposable elements ({TE}s) in the adaptive processes of this species has not been studied yet. {A}s a first step toward assessing the role of {TE}s in rapid urban adaptation, we sequenced using long reads six {A}n. coluzzii genomes from natural breeding sites in two major {C}entral {A}frica cities. {W}e de novo annotated {TE}s in these genomes and in an additional high-quality {A}n. coluzzii genome, and we identified 64 new {TE} families. {TE}s were nonrandomly distributed throughout the genome with significant differences in the number of insertions of several superfamilies across the studied genomes. {W}e identified seven putatively active families with insertions near genes with functions related to vectorial capacity, and several {TE}s that may provide promoter and transcription factor binding sites to insecticide resistance and immune-related genes. {O}verall, the analysis of multiple high-quality genomes allowed us to generate the most comprehensive {TE} annotation in this species to date and identify several {TE} insertions that could potentially impact both genome architecture and the regulation of functionally relevant genes. {T}hese results provide a basis for future studies of the impact of {TE}s on the biology of {A}n. coluzzii.},
  keywords = {},
  booktitle = {},
  journal = {{G}enome {R}esearch},
  volume = {32},
  numero = {1},
  pages = {189--202},
  ISSN = {1088-9051},
  year = {2022},
  DOI = {10.1101/gr.275761.121},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00023992},
}