@article{PAR00023384,
  title = {{M}ultidrug-resistant {K}lebsiella pneumoniae clones from wild chimpanzees and termites in {S}enegal},
  author = {{B}aron, {S}. {A}. and {M}ediannikov, {O}leg and {A}bdallah, {R}. and {Y}imagou, {E}. {K}. and {M}edkour, {H}ac{\`e}ne and {D}ubourg, {G}. and {E}lamire, {Y}. and {A}fouda, {P}. and {N}gom,, {II} and {A}ngelakis, {E}. and {D}avoust, {B}. and {D}iatta, {G}eorges and {B}arciela, {A}. and {H}ernandez-{A}guilar, {R}. {A}. and {S}okhna, {C}heikh and {C}aputo, {A}. and {L}evasseur, {A}. and {R}olain, {J}. {M}. and {R}aoult, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ntibiotic resistance genes exist naturally in various environments far from human usage. {H}ere, we investigated multidrug-resistant {K}lebsiella pneumoniae, a common pathogen of chimpanzees and humans. {W}e screened antibiotic-resistant {K} pneumoniae from 48 chimpanzee stools and 38 termite mounds (n=415 samples) collected in protected areas in {S}enegal. {T}he microsatellite method was used to identify chimpanzee individuals (n =13). {W}hole-genome sequencing was performed on {K} pneumoniae complex isolates to identify antibiotic-resistant genes and characterize clones. {W}e found a high prevalence of carbapenem-resistant {K}. pneumoniae among chimpanzee isolates (18/48 samples from 7/13 individuals) and ceftriaxone resistance among both chimpanzee individuals (19/48) and termite mounds (7/415 termites and 3/38 termite mounds). {T}he bla({OXA}-48) and the bla({KPC}-2) genes were carried by international p{OXA}-48 and p{KPC}-2 plasmids, respectively. {T}he {ESBL} plasmid carried bla({CTX}-{M})(-15), bla({TEM}-18), and bla({OXA})(-1), genes. {G}enome sequencing of 56 isolates identified two major clones associated with hospital-acquired infections of {K}. pneumoniae ({ST}307 and {ST}147) in chimpanzees and termites, suggesting circulation of strains between the two species, as chimpanzees feed on termites. {T}he source and selection pressure of these clones in this environment need to be explored.},
  keywords = {carbapenemases ; chimpanzee ; {ESBL} ; {K}iebsielia pneumoniae ; {ST}147 ; {ST}307 ; wildlife ; antibiotic resistance ; termite mounds ; {SENEGAL}},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {65},
  numero = {9},
  pages = {e02557--20 []},
  ISSN = {0066-4804},
  year = {2021},
  DOI = {10.1128/aac.02557-20},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00023384},
}