Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Travel Medicine and Infectious Disease 102105 [9 ] Fever Bacteraemia Malaria Salmonella enterica Streptococcus pneumoniae Cote d'Ivoire COTE D'IVOIRE 2021 PAR00023336 ENG Travel Medicine and Infectious Disease 1477-8939 ISI:000693407400024 10.1016/j.tmaid.2021.102105 https://www.documentation.ird.fr/hor/PAR00023336 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-10/010082787.pdf 43 Horizon (IRD) Background: The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Cote d'Ivoire. Methods: Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools. Results: Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p < 0.001). Bacteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). Streptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p < 0.001). Non-typhoidal Salmonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p < 0.001). Salmonella enterica Typhi and S. enterica Paratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as Tropheryma whipplei (0.9%), Streptococcus pyogenes (0.7%), and Plasmodium ovale (4.6%). The prevalence in febrile and afebrile people was similar for Staphylococcus aureus (3.6-4.9%), Rickettsia felis (5.5-6.4%), Mansonella perstans (3.0-3.2%), and Plasmodium malariae (1.6-2.3%). Comorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving P. falciparum. All patients co-infected with P. falciparum and S. pneumoniae were febrile whereas 30% of those infected by P. falciparum alone were not (p = 0.02). Among febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy. Conclusion: Identification of etiologies of acute febrile diseases in sub-Saharan Africa proposes keys to successful treatment and prevention of infectious diseases. Vaccination campaigns may decrease the morbidity of monoand co-infections by preventable microorganisms. 050 ; 052 ; 084 UR257 / UR258 Côte d'ivoire / Gabon