@article{PAR00021144,
  title = {{C}irculating cytokines associated with poor pregnancy outcomes in {B}eninese exposed to infection with {P}lasmodium falciparum},
  author = {{H}ountohotegbe, {T}. and {G}bedande, {K}. and {A}gbota, {G}ino and {I}bitokou, {S}. and {M}assougbodji, {A}. and {D}eloron, {P}hilippe and {F}ievet, {N}adine and {L}uty, {A}drian},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. {P}revious studies, including our own, suggested that placental and peripheral cytokine and chemokine levels measured at delivery can be used as biomarkers for pregnancy outcomes. {H}owever, the timing of malaria infection during pregnancy matters, and these studies do not address the effect of different cytokines in peripheral blood plasma samples taken at early and midpregnancy and at delivery. {H}ere, we aimed to investigate whether peripheral plasma cytokine levels were associated with pregnancy outcomes in a cohort of 400 {B}eninese pregnant women. {U}sing a high-sensitivity cytometry-based method, we quantified the levels of interleukin-4 ({IL}-4), {IL}-5, {IL}-10, {IL}-12p70, and gamma interferon ({IFN}-gamma) in peripheral plasma samples taken at two time points during pregnancy and at delivery in various groups of pregnant women identified with {P}lasmodium falciparum infection, with anemia, with preterm births, or giving birth to babies who are small for their gestational age. {W}e found that, consistently at all time points, elevated levels of {IL}-10 were strongly and significantly associated with {P}. falciparum infection, while the levels of {IFN}-gamma at inclusion and delivery were weakly but also significantly associated. {L}ow levels of {IL}-5 at delivery were associated with a greater risk of both preterm births and small-for-gestational-age babies. {T}he immunosuppressive effects of {IL}-10 likely affect the overall cytokine equilibrium during pregnancy in women harboring {P}. falciparum infections. {O}ur findings highlight the peripheral signature of pregnancy outcomes and strengthen the idea of using cytokines as diagnostic or prognostic markers.},
  keywords = {cytokine ; malaria ; pregnancy outcomes ; {BENIN}},
  booktitle = {},
  journal = {{I}nfection and {I}mmunity},
  volume = {88},
  numero = {8},
  pages = {e00042--20 [15 ]},
  ISSN = {0019-9567},
  year = {2020},
  DOI = {10.1128/iai.00042-20},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00021144},
}