Hountohotegbe T., Gbedande K., Agbota Gino, Ibitokou S., Massougbodji A., Deloron Philippe, Fievet Nadine, Luty Adrian. (2020). Circulating cytokines associated with poor pregnancy outcomes in Beninese exposed to infection with Plasmodium falciparum. Infection and Immunity, 88 (8), e00042-20 [15 p.]. ISSN 0019-9567.
Titre du document
Circulating cytokines associated with poor pregnancy outcomes in Beninese exposed to infection with Plasmodium falciparum
Année de publication
2020
Auteurs
Hountohotegbe T., Gbedande K., Agbota Gino, Ibitokou S., Massougbodji A., Deloron Philippe, Fievet Nadine, Luty Adrian
Source
Infection and Immunity, 2020,
88 (8), e00042-20 [15 p.] ISSN 0019-9567
Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies, including our own, suggested that placental and peripheral cytokine and chemokine levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters, and these studies do not address the effect of different cytokines in peripheral blood plasma samples taken at early and midpregnancy and at delivery. Here, we aimed to investigate whether peripheral plasma cytokine levels were associated with pregnancy outcomes in a cohort of 400 Beninese pregnant women. Using a high-sensitivity cytometry-based method, we quantified the levels of interleukin-4 (IL-4), IL-5, IL-10, IL-12p70, and gamma interferon (IFN-gamma) in peripheral plasma samples taken at two time points during pregnancy and at delivery in various groups of pregnant women identified with Plasmodium falciparum infection, with anemia, with preterm births, or giving birth to babies who are small for their gestational age. We found that, consistently at all time points, elevated levels of IL-10 were strongly and significantly associated with P. falciparum infection, while the levels of IFN-gamma at inclusion and delivery were weakly but also significantly associated. Low levels of IL-5 at delivery were associated with a greater risk of both preterm births and small-for-gestational-age babies. The immunosuppressive effects of IL-10 likely affect the overall cytokine equilibrium during pregnancy in women harboring P. falciparum infections. Our findings highlight the peripheral signature of pregnancy outcomes and strengthen the idea of using cytokines as diagnostic or prognostic markers.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010087127]
Identifiant IRD
PAR00021144
