@article{PAR00014437,
  title = {{G}enome-wide association study of antibody responses to {P}lasmodium falciparum candidate vaccine antigens},
  author = {{M}ilet, {J}acqueline and {S}abbagh, {A}. and {M}igot {N}abias, {F}lorence and {L}uty, {A}. {J}. {F}. and {G}aye, {O}. and {G}arcia, {A}ndr{\'e} and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e conducted a genome-wide association study ({GWAS}) of antibody responses directed to three {P}lasmodium falciparum vaccine candidate antigens ({MSP}1, {MSP}2 and {GLURP}) previously associated with different patterns of protection against malaria infection in {S}enegalese children. {A} total of 174 950 single-nucleotide polymorphisms ({SNP}s) were tested for association with immunoglobulin {G}1 ({I}g{G}1) responses directed to {MSP}1 and to {GLURP} and with {I}g{G}3 responses to {MSP}2 {FC}27 and to {MSP}2 3{D}7. {W}e first performed a single-trait analysis with each antibody response and then a multiple-trait analysis in which we analyzed simultaneously the three immune responses associated with the control of clinical malaria episodes. {S}uggestive associations ({P} < 1x10(-4)) were observed for 25 {SNP}s in {MSP}1 antibody response analysis or in multiple-trait analysis. {A}ccording to the strength of their observed associations and their functional role, the following genes are of particular interest: {RASGRP}3 (2p22.3, {P} = 7.6 x 10(-6)), {RIMS}1 (6q13, {P} = 2.0 x 10(-5)), {MVB}12{B} (9q33.3, {P} = 8.9 x 10(-5)) and {GNPTAB} (12q23.2, {P} = 7.4 x 10(-5)). {F}uture studies will be required to replicate these findings in other {A}frican populations. {T}his work will contribute to the elucidation of the host genetic factors underlying variable immune responses to {P}. falciparum.},
  keywords = {},
  booktitle = {},
  journal = {{G}enes and {I}mmunity},
  volume = {17},
  numero = {2},
  pages = {110--117},
  ISSN = {1466-4879},
  year = {2016},
  DOI = {10.1038/gene.2015.59},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014437},
}