@article{PAR00011683,
  title = {{L}ooking for the bird {K}iss : evolutionary scenario in sauropsids},
  author = {{P}asquier, {J}. and {L}afont, {A}. {G}. and {R}ousseau, {K}. and {Q}uerat, {B}. and {C}hemineau, {P}. and {D}ufour, {S}ylvie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he neuropeptide {K}iss and its receptor {K}iss{R} are key-actors in the brain control of reproduction in mammals, where they are responsible for the stimulation of the activity of {G}n{RH} neurones. {I}nvestigation in other vertebrates revealed up to 3 {K}iss and 4 {K}iss{R} paralogs, originating from the two rounds of whole genome duplication in early vertebrates. {I}n contrast, the absence of {K}iss and {K}iss{R} has been suggested in birds, as no homologs of these genes could be found in current genomic databases. {T}his study aims at addressing the question of the existence, from an evolutionary perspective, of the {K}isspeptin system in birds. {I}t provides the first large-scale investigation of the {K}isspeptin system in the sauropsid lineage, including ophidian, chelonian, crocodilian, and avian lineages. {R}esults: {S}auropsid {K}iss and {K}iss{R} genes were predicted from multiple genome and transcriptome databases by {TBLASTN}. {P}hylogenetic and syntenic analyses were performed to classify predicted sauropsid {K}iss and {K}iss{R} genes and to reconstruct the evolutionary scenarios of both gene families across the sauropsid radiation. {G}enome search, phylogenetic and synteny analyses, demonstrated the presence of two {K}iss genes ({K}iss1 and {K}iss2 types) and of two {K}iss{R} genes ({K}iss{R}1 and {K}iss{R}4 types) in the sauropsid lineage. {T}hese four genes, also present in the mammalian lineage, would have been inherited from their common amniote ancestor. {I}n contrast, synteny analyses supported that the other {K}iss and {K}iss{R} paralogs are missing in sauropsids as in mammals, indicating their absence in the amniote lineage. {A}mong sauropsids, in the avian lineage, we demonstrated the existence of a {K}iss2-like gene in three bird genomes. {T}he divergence of these avian {K}iss2-like sequences from those of other vertebrates, as well as their absence in the genomes of some other birds, revealed the processes of {K}iss2 gene degeneration and loss in the avian lineage. {C}onclusion: {T}hese findings contribute to trace back the evolutionary history of the {K}isspeptin system in amniotes and sauropsids, and provide the first molecular evidence of the existence and fate of a {K}iss gene in birds.},
  keywords = {{K}isspeptin ; {K}iss receptor ; {P}hylogeny ; {S}ynteny ; {A}mniotes ; {S}auropsids ; {B}irds},
  booktitle = {},
  journal = {{B}mc {E}volutionary {B}iology},
  volume = {14},
  numero = {},
  pages = {art. 30},
  ISSN = {1471-2148},
  year = {2014},
  DOI = {10.1186/1471-2148-14-30},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011683},
}