@article{PAR00011681,
  title = {{A}ssociation of adipose tissue and liver fibrosis with tissue stiffness in morbid obesity : links with diabetes and {BMI} loss after gastric bypass},
  author = {{A}bdennour, {M}. and {R}eggio, {S}. and {L}e {N}aour, {G}. and {L}iu, {Y}. {J}. and {P}oitou, {C}. and {A}ron-{W}isnewsky, {J}. and {C}harlotte, {F}. and {B}ouillot, {J}. {L}. and {T}orcivia, {A}. and {S}asso, {M}. and {M}iette, {V}. and {Z}ucker, {J}ean-{D}aniel and {B}edossa, {P}. and {T}ordjman, {J}. and {C}lement, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ontext: {L}iver and white adipose tissue ({WAT}) develop inflammation and fibrosis. {O}bjective: {T}he aim of the study was to evaluate the bioclinical relevance of {WAT} fibrosis in morbid obesity and diabetes and the relationships with tissue stiffness measured using a novel device. {D}esign and {S}etting: {O}bservational and longitudinal studies were conducted in a hospital nutrition department. {P}atients: {B}iopsies of liver and subcutaneous {WAT} (sc{WAT}) and omental adipose tissue were collected from 404 obese bariatric surgery candidates, of whom 243 were clinically characterized before surgery and 3, 6, and 12 months after surgery. {I}n 123 subjects, liver and sc{WAT} stiffness was assessed noninvasively using vibration-controlled transient elastography ({VCTE}). {I}nterventions: {B}ariatric surgery was performed for some patients. {M}ain {O}utcome {M}easure: {A}dipose tissue fibrosis and stiffness and their link to obesity phenotypes were measured. {R}esults: sc{WAT} fibrosis was positively associated with liver fibrosis (fibrosis score >= 2) (rho = 0.14; {P} = .01). {VCTE}-evaluated liver and sc{WAT} stiffness was positively correlated with immunohistochemistry-determined liver (rho = 0.46; {P} = .0009) and sc{WAT} fibrosis (rho = 0.48; {P} = .0001). {VCTE}-evaluated sc{WAT} stiffness measures negatively associated with dual-energy x-ray absorptiometry-evaluated body fat mass ({R} = -0.25; {P} = .009) and were correlated with metabolic variables. {D}iabetic subjects showed increased sc{WAT} stiffness. {P}articipants less responsive to gastric bypass were older and more frequently diabetic, and they had increased body mass index, serum {IL}-6, and sc{WAT} and liver fibrosis. {S}ubjects with no diabetes and normal liver had higher fat mass and lower tissue fibrosis and stiffness. {C}onclusion: sc{WAT} stiffness was associated with tissue fibrosis, obesity, and diabetes-related traits. {N}oninvasive evaluation of sc{WAT} stiffness might be useful in clinical practice.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {C}linical {E}ndocrinology and {M}etabolism},
  volume = {99},
  numero = {3},
  pages = {898--907},
  ISSN = {0021-972{X}},
  year = {2014},
  DOI = {10.1210/jc.2013-3253},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011681},
}