@article{PAR00009580,
  title = {{R}ickettsia species in {A}frican {A}nopheles mosquitoes},
  author = {{S}ocolovschi, {C}. and {P}ages, {F}. and {N}diath, {M}amadou {O}usmane and {R}atmanov, {P}avel and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}here is higher rate of {R}. felis infection among febrile patients than in healthy people in {S}ub-{S}aharan {A}frica, predominantly in the rainy season. {M}osquitoes possess a high vectorial capacity and, because of their abundance and aggressiveness, likely play a role in rickettsial epidemiology. {M}ethodology/{P}rincipal {F}indings: {Q}uantitative and traditional {PCR} assays specific for {R}ickettsia genes detected rickettsial {DNA} in 13 of 848 (1.5%) {A}nopheles mosquitoes collected from {C}ote d'{I}voire, {G}abon, and {S}enegal. {R}. felis was detected in one {A}n. gambiae molecular form {S} mosquito collected from {K}ahin, {C}ote d'{I}voire (1/77, 1.3%). {A}dditionally, a new {R}ickettsia genotype was detected in five {A}n. gambiae molecular form {S} mosquitoes collected from {C}ote d'{I}voire (5/77, 6.5%) and one mosquito from {L}ibreville, {G}abon (1/88, 1.1%), as well as six {A}n. melas (6/67, 9%) mosquitoes collected from {P}ort {G}entil, {G}abon. {A} sequence analysis of the glt{A}, omp{B}, omp{A} and sca4 genes indicated that this new {R}ickettsia sp. is closely related to {R}. felis. {N}o rickettsial {DNA} was detected from {A}n. funestus, {A}n. arabiensis, or {A}n. gambiae molecular form {M} mosquitoes. {A}dditionally, a {BLAST} analysis of the glt{A} sequence from the new {R}ickettsia sp. resulted in a 99.71% sequence similarity to a species ({JQ}674485) previously detected in a blood sample of a {S}enegalese patient with a fever from the {B}andafassi village, {K}edougou region. {C}onclusion: {R}. felis was detected for the first time in {A}n. gambiae molecular form {S}, which represents the major {A}frican malaria vector. {T}he discovery of {R}. felis, as well as a new {R}ickettsia species, in mosquitoes raises new issues with respect to {A}frican rickettsial epidemiology that need to be investigated, such as bacterial isolation, the degree of the vectorial capacity of mosquitoes, the animal reservoirs, and human pathogenicity.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {10},
  pages = {e48254},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0048254},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00009580},
}