@article{PAR00009545,
  title = {{M}odularity as a source of new morphological variation in the mandible of hybrid mice},
  author = {{R}enaud, {S}. and {A}libert, {P}. and {A}uffray, {J}ean-{C}hristophe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {H}ybridization is often seen as a process dampening phenotypic differences accumulated between diverging evolutionary units. {F}or a complex trait comprising several relatively independent modules, hybridization may however simply generate new phenotypes, by combining into a new mosaic modules inherited from each parental groups and parts intermediate with respect to the parental groups. {W}e tested this hypothesis by studying mandible size and shape in a set of first and second generation hybrids resulting from inbred wild-derived laboratory strains documenting two subspecies of house mice, {M}usmusculus domesticus and {M}usmusculus musculus. {P}henotypic variation of the mandible was divided into nested partitions of developmental, evolutionary and functional modules. {R}esults: {T}he size and shape of the modules were differently influenced by hybridization. {S}ome modules seemed to be the result of typical additive effects with hybrids intermediate between parents, some displayed a pattern expected in the case of monogenic dominance, whereas in other modules, hybrids were transgressive. {T}he result is interpreted as the production of novel mandible morphologies. {B}eyond this modularity, modules in functional interaction tended to display significant covariations. {C}onclusions: {M}odularity emerges as a source of novel morphological variation by its simple potential to combine different parts of the parental phenotypes into a novel offspring mosaic of modules. {T}his effect is partly counterbalanced by bone remodeling insuring an integration of the mosaic mandible into a functional ensemble, adding a non-genetic component to the production of transgressive phenotypes in hybrids.},
  keywords = {{M}us musculus ; {H}ouse mouse ; {M}andible shape ; {H}ybridization ; {G}eometric ; morphometrics ; {T}ransgressive phenotypes},
  booktitle = {},
  journal = {{B}mc {E}volutionary {B}iology},
  volume = {12},
  numero = {},
  pages = {141},
  ISSN = {1471-2148},
  year = {2012},
  DOI = {10.1186/1471-2148-12-141},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00009545},
}