@article{PAR00009331,
  title = {{I}ntegrative study of pandemic {A}/{H}1{N}1 influenza infections : design and methods of the {C}o{P}an{F}lu-{F}rance cohort},
  author = {{L}apidus, {N}. and {D}e {L}amballerie, {X}avier and {S}alez, {N}. and {S}etbon, {M}. and {F}errari, {P}. and {D}elabre, {R}. {M}. and {G}ougeon, {M}. {L}. and {V}ely, {F}. and {L}eruez-{V}ille, {M}. and {A}ndreoletti, {L}. and {C}auchemez, {S}. and {B}oelle, {P}. {Y}. and {V}ivier, {E}. and {A}bel, {L}. and {S}chwarzinger, {M}. and {L}egeas, {M}. and {L}e {C}ann, {P}. and {F}lahault, {A}. and {C}arrat, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he risk of influenza infection depends on biological characteristics, individual or collective behaviors and the environmental context. {T}he {C}ohorts for {P}andemic {I}nfluenza ({C}o{P}an{F}lu) {F}rance study was set up in 2009 after the identification of the novel swine-origin {A}/{H}1{N}1 pandemic influenza virus. {T}his cohort of 601 households (1450 subjects) representative for the general population aims at using an integrative approach to study the risk and characteristics of influenza infection as a complex combination of data collected from questionnaires regarding sociodemographic, medical, behavioral characteristics of subjects and indoor environment, using biological samples or environmental databases. {M}ethods/{D}esign: {H}ouseholds were included between {D}ecember 2009 and {J}uly 2010. {T}he design of this study relies on systematic follow-up visits between influenza seasons and additional visits during influenza seasons, when an influenza-like illness is detected in a household via an active surveillance system. {D}uring systematic visits, a nurse collects individual and environmental data on questionnaires and obtains blood samples from all members of the household. {W}hen an influenza-like-illness is detected, a nurse visits the household three times during the 12 following days, and collects data on questionnaires regarding exposure and symptoms, and biological samples (including nasal swabs) from all subjects in the household. {T}he end of the follow-up period is expected in fall 2012. {D}iscussion: {T}he large amount of data collected throughout the follow-up will permit a multidisciplinary study of influenza infections. {A}dditional data is being collected and analyzed in this ongoing cohort. {T}he longitudinal analysis of these households will permit integrative analyses of complex phenomena such as individual, collective and environmental risk factors of infection, routes of transmission, or determinants of the immune response to infection or vaccination.},
  keywords = {{I}nfluenza a virus {H}1{N}1 subtype ; {C}ohort study ; {R}isk factors ; {F}rance},
  booktitle = {},
  journal = {{B}mc {P}ublic {H}ealth},
  volume = {12},
  numero = {},
  pages = {417},
  ISSN = {1471-2458},
  year = {2012},
  DOI = {10.1186/1471-2458-12-417},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00009331},
}