@article{PAR00009157,
  title = {{C}omparative meta-analysis of the effect of {L}actobacillus species on weight gain in humans and animals},
  author = {{M}illion, {M}. and {A}ngelakis, {E}. and {P}aul, {M}. and {A}rmougom, {F}abrice and {L}eibovici, {L}. and {R}aoult, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {O}besity is associated with alteration of the gut microbiota. {I}n order to clarify the effect of {L}actobacillus-containing probiotics ({LCP}) on weight we performed a meta-analysis of clinical studies and experimental models. {W}e intended to assess effects by {L}actobacillus species. {M}ethods: {A} broad search with no date or language restriction was performed. {W}e included randomized controlled trials ({RCT}s) and comparative clinical studies in humans and animals or experimental models assessing the effect of {L}actobacillus-containing probiotics on weight. {W}e primarily attempted to extract and use change from baseline values. {D}ata were extracted independently by two authors. {R}esults were pooled by host and by {L}actobacillus species and are summarized in a meta-analysis of standardized difference in means ({SMD}s). {R}esults: {W}e identified and included 17 {RCT}s in humans, 51 studies on farm animals and 14 experimental models. {L}actobacillus acidophilus administration resulted in significant weight gain in humans and in animals ({SMD} 0.15; 95% confidence intervals 0.05-0.25). {R}esults were consistent in humans and animals. {L}actobacillus fermentum and {L}actobacillus ingluviei were associated with weight gain in animals. {L}actobacillus plantarum was associated with weight loss in animals and {L}actobacillus gasseri was associated with weight loss both in obese humans and in animals. {C}onclusions: {D}ifferent {L}actobacillus species are associated different effects on weight change that are host-specific. {F}urther studies are needed to clarify the role of {L}actobacillus species in the human energy harvest and weight regulation. {A}ttention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain.},
  keywords = {{P}robiotics ; {L}actobacillus ; {W}eight ; {O}besity ; {M}eta-analysis},
  booktitle = {},
  journal = {{M}icrobial {P}athogenesis},
  volume = {53},
  numero = {2},
  pages = {100--108},
  ISSN = {0882-4010},
  year = {2012},
  DOI = {10.1016/j.micpath.2012.05.007},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00009157},
}