@article{PAR00008957, title = {{R}eclassification of giant viruses composing a fourth domain of life in the new order megavirales}, author = {{C}olson, {P}. and de {L}amballerie, {X}avier and {F}ournous, {G}. and {R}aoult, {D}idier}, editor = {}, language = {{ENG}}, abstract = {{I}nterest in giant viruses has risen sharply since 2003, following the discovery of the {M}imivirus and four other protist-infecting giant viruses that are linked to the nucleocytoplasmic large {DNA} viruses ({NCLDV}s). {D}espite considerable heterogeneity in hosts and genome sizes, the {NCLDV}s have been shown to be monophyletic based on analyses of their sequences and gene repertoires and recent studies have proposed that these viruses share a common ancient ancestor and compose a fourth domain of life. {I}n addition, several characteristics of these giant viruses contradict or do not match the criteria used for the canonical definition of viruses, and the {NCLDV} denomination is not completely appropriate. {W}e propose here to define a new viral order named {M}egavirales.}, keywords = {{M}egavirales ; {G}iant virus ; {A}canthamoeba polyphaga {M}imivirus ; {M}imiviridae ; {N}ucleocytoplasmic large {DNA} viruses ; {A}moeba ; {A}canthamoeba spp. ; {P}hagocytic protist ; {C}lassification ; {D}omains of life}, booktitle = {}, journal = {{I}ntervirology}, volume = {55}, numero = {5}, pages = {321--332}, ISSN = {0300-5526}, year = {2012}, DOI = {10.1159/000336562}, URL = {https://www.documentation.ird.fr/hor/{PAR}00008957}, }