@article{PAR00008949,
  title = {{T}he viral etiology of an influenza-like illness during the 2009 pandemic},
  author = {{T}hiberville, {S}. {D}. and {N}inove, {L}. and {H}ai, {V}. {V}. and {B}otelho-{N}evers, {E}. and {G}azin, {C}. and {T}hirion, {L}. and {S}alez, {N}. and de {L}amballerie, {X}avier and {C}harrel, {R}. and {B}rouqui, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}any viruses are known to cause influenza-like illness ({ILI}); however, in nearly 50% of patients, the etiologic agent remains unknown. {T}he distribution of viruses in patients with {ILI} was investigated during the 2009 {A}/{H}1{N}1 influenza pandemic ({A}/{H}1{N}1p). {F}rom {J}une 2009 to {J}anuary 2010, 660 patients with suspected influenza were questioned and examined, and nasal swabs were collected. {A}ll patient samples were tested for influenza virus, and 286 negative nasal swabs were tested further for 18 other respiratory viruses using real-time {RT}-{PCR}. {T}wo waves of {ILI} were observed in the epidemic curve (weeks 3542 and 4249). {A}t least eight viruses co-circulated during this period: human rhinovirus ({HRV}) (58), parainfluenza 14 viruses ({PIV}) (9), human {C}oronavirus (h{C}o{V}) {OC}43 (9), enterovirus (5), adenovirus ({A}d{V}) (4), and human metapneumovirus (h{MPV}) (2); however, 204 samples remained negative for all viruses tested. {ILI} symptoms, according to the {C}enters for {D}isease {C}ontrol and {P}revention criteria for {ILI} definition, were reported in 75% of cases. {T}hese patients had positive swabs for {A}/{H}1{N}1p, {HRV}, h{C}o{V}-{OC}43, {PIV}, {A}d{V}, and h{MPV} without significant difference with non-{ILI} patients. {T}his study found that many respiratory viruses circulated during this period and that the {A}/{H}1{N}1p did not impact on the kinetics of other respiratory viruses. {T}he proportion of non-documented cases remains high. {ILI} could not distinguish {A}/{H}1{N}1p infection from that due to other respiratory viruses. {H}owever, in multivariate anlaysis, cough, chills, hyperemia, and dyspnea were associated significantly with influenza virus versus other respiratory viruses. {J}. {M}ed. {V}irol. 84: 10711079, 2012.},
  keywords = {respiratory viruses ; influenza {A} virus ; {A} ; {H}1{N}1p subtype ; rhinovirus ; influenza-like-illness ; acute respiratory tract infection},
  booktitle = {},
  journal = {{J}ournal of {M}edical {V}irology},
  volume = {84},
  numero = {7},
  pages = {1071--1079},
  ISSN = {0146-6615},
  year = {2012},
  DOI = {10.1002/jmv.23265},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00008949},
}