%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Cardenas, C.L.L.
%A Devos, A.
%A Toure, A.
%A Garcia, J.C.
%A Kenani, A.
%A Migot Nabias, Florence
%A Broly, F.
%A Chevalier, D.
%T Arachidonic acid omega-hydroxylase CYP4A11 : inter-ethnic variations in the 8590T > C loss-of-function variant
%D 2012
%L PAR00008530
%G ENG
%J Molecular Biology Reports
%@ 0301-4851
%K Cytochrome P450 ; Arachidonic acid ; CYP4A11 ; 20-Hydroxyeicosatetraenoic acid ; Genetic polymorphisms ; Inter-ethnic variations
%K SENEGAL ; GABON ; TUNISIE ; PEROU ; FRANCE
%M ISI:000298751300085
%N 2
%P 1503-1508
%R 10.1007/s11033-011-0888-x
%U https://www.documentation.ird.fr/hor/PAR00008530
%> https://www.documentation.ird.fr/intranet/publi/2012/02/010054324.pdf
%V 39
%W Horizon (IRD)
%X The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). Previous studies have reported a significant association between the 8590T > C genetic variant of CYP4A11 and hypertension. Interestingly, several population-based studies have reported ethnic differences in the prevalence of hypertension, with the highest prevalence in African populations. The aim of this work was to determine the frequency and inter-ethnic comparison of the CYP4A11 (8590T > C) functional polymorphism, in five new ethnic groups: European (99 French Caucasians), African (36 Gabonese and 50 Senegalese), South American (60 Peruvians) and North African (53 Tunisians) populations, using polymerase chain reaction-single strand conformational polymorphism and sequencing strategies. We confirmed that the CYP4A11 (8590T > C) functional polymorphism exhibits inter-ethnic frequency differences. Noteworthy, the highest 8590C allele frequency was observed in the Tunisian (30.2%), followed by Senegalese (20%) populations. In addition, the CC genotype was only found in the Gabonese and Tunisian populations (5.6% and 8.4%, respectively). These populations may be of major interest to help to clarify the linkage between hypertension and CYP4A11 (8590T > C) genotype in African populations. These findings provide data for further studies that investigate the potential association of CYP4A11 (8590T > C) variant with an incidence of hypertension genesis in respect of ethnicity.
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