@article{PAR00008530,
  title = {{A}rachidonic acid omega-hydroxylase {CYP}4{A}11 : inter-ethnic variations in the 8590{T} > {C} loss-of-function variant},
  author = {{C}ardenas, {C}.{L}.{L}. and {D}evos, {A}. and {T}oure, {A}. and {G}arcia, {J}.{C}. and {K}enani, {A}. and {M}igot {N}abias, {F}lorence and {B}roly, {F}. and {C}hevalier, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he human {C}ytochrome {P}450 4{A}11 ({CYP}4{A}11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-{HETE}). {P}revious studies have reported a significant association between the 8590{T} > {C} genetic variant of {CYP}4{A}11 and hypertension. {I}nterestingly, several population-based studies have reported ethnic differences in the prevalence of hypertension, with the highest prevalence in {A}frican populations. {T}he aim of this work was to determine the frequency and inter-ethnic comparison of the {CYP}4{A}11 (8590{T} > {C}) functional polymorphism, in five new ethnic groups: {E}uropean (99 {F}rench {C}aucasians), {A}frican (36 {G}abonese and 50 {S}enegalese), {S}outh {A}merican (60 {P}eruvians) and {N}orth {A}frican (53 {T}unisians) populations, using polymerase chain reaction-single strand conformational polymorphism and sequencing strategies. {W}e confirmed that the {CYP}4{A}11 (8590{T} > {C}) functional polymorphism exhibits inter-ethnic frequency differences. {N}oteworthy, the highest 8590{C} allele frequency was observed in the {T}unisian (30.2%), followed by {S}enegalese (20%) populations. {I}n addition, the {CC} genotype was only found in the {G}abonese and {T}unisian populations (5.6% and 8.4%, respectively). {T}hese populations may be of major interest to help to clarify the linkage between hypertension and {CYP}4{A}11 (8590{T} > {C}) genotype in {A}frican populations. {T}hese findings provide data for further studies that investigate the potential association of {CYP}4{A}11 (8590{T} > {C}) variant with an incidence of hypertension genesis in respect of ethnicity.},
  keywords = {{C}ytochrome {P}450 ; {A}rachidonic acid ; {CYP}4{A}11 ; 20-{H}ydroxyeicosatetraenoic acid ; {G}enetic polymorphisms ; {I}nter-ethnic variations ; {SENEGAL} ; {GABON} ; {TUNISIE} ; {PEROU} ; {FRANCE}},
  booktitle = {},
  journal = {{M}olecular {B}iology {R}eports},
  volume = {39},
  numero = {2},
  pages = {1503--1508},
  ISSN = {0301-4851},
  year = {2012},
  DOI = {10.1007/s11033-011-0888-x},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00008530},
}