@article{PAR00008487,
  title = {{D}ifferential regulation of the expression of cytochrome {P}450 aromatase, estrogen and androgen receptor subtypes in the brain-pituitary-ovarian axis of the {J}apanese eel ({A}nguilla japonica) reveals steroid dependent and independent mechanisms},
  author = {{J}eng, {S}. {R}. and {P}asquier, {J}. and {Y}ueh, {W}. {S}. and {C}hen, {G}. {R}. and {L}ee, {Y}. {H}. and {D}ufour, {S}ylvie and {C}hang, {C}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study aimed at investigating the role of sexual steroids in the regulation of the expression of the single aromatase gene and steroid receptor subtypes in the brain-pituitary-ovarian axis of the {J}apanese eel. {U}nlike other teleosts, which possess duplicated genes for aromatase, cyp19a1a and cyp19a1b, expressed in the gonads and in the brain, respectively, eel species possess a single cyp19a1. {P}hylogenetic analysis indicated that eel brain/gonadal cyp19a1 branches at the basis of both teleost gonadal cyp19a1 a and brain cyp19a1b clades. {F}emale eels treated with catfish pituitary homogenate ({CPH}) to induce sexual maturation showed an increase in the expression of cyp19a1 and aromatase enzymatic activity in the brain and in. the ovaries. {T}reatments with sex steroids (estradiol-17 beta, {E}(2) or testosterone, {T}) revealed that the increase in cyp19a1 expression in the brain may result from {E}(2)-specific induction. {I}n contrast, the increase in cyp19a1 expression in the ovaries of {CPH}-treated eels is a result of steroid-independent control, probably from a direct effect of gonadotropins contained in the pituitary extract. {A}nalysis of the expression of estrogen and androgen receptor subtypes, esr-alpha. esr-beta,ar-alpha and ar-beta, in eels treated with {CPH} or sex steroids revealed differential regulations. {I}n {CPH}-treated eels, the expression of esr-alpha and ar-alpha was significantly increased in the brain, while the expression of ar-alpha and ar-beta was increased in the ovaries. {N}o change was. observed in esr-beta in any organ. {S}teroid treatments induced an upregulation by {E}(2) of esr-alpha, but not esr-beta expression, in the brain, pituitary and ovaries, while no autoregulation by {T} of its own receptors could be observed. {T}hese results reveal both steroid-dependent and -independent mechanisms in the regulation of cyp19a1 and steroid receptor subtype expression in the eel.},
  keywords = {{A}romatase ; {S}teroid receptor ; {E}stradiol ; {T}estosterone ; {E}el ; {T}eleost},
  booktitle = {},
  journal = {{G}eneral and {C}omparative {E}ndocrinology},
  volume = {175},
  numero = {1},
  pages = {163--172},
  ISSN = {0016-6480},
  year = {2012},
  DOI = {10.1016/j.ygcen.2011.11.005},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00008487},
}