@article{PAR00008281,
  title = {{E}pidemiology of concomitant infection due to {L}oa loa and {M}ansonella perstans in {G}abon},
  author = {{A}kue, {J}. {P}. and {N}koghe, {D}. and {P}adilla, {C}. and {M}oussavou, {G}. and {M}oukana, {H}. and {M}bou, {R}. {A}. and {O}llomo, {B}. and {L}eroy, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he filarial parasites {L}oa loa and {M}ansonnella perstans are endemic in the central and western {A}frican forest block. {L}oa loa is pathogenic and represents a major obstacle to the control of co-endemic filariae because its treatment can cause fatal complications such as encephalitis. {M}ethodology/{P}rincipal {F}indings: 4392 individuals aged over 15 years were studied both by direct examination and a concentration technique. {T}he overall prevalence rates were 22.4% for {L}oa loa microfilaremia, 10.2% for {M}. perstans microfilaremia, and 3.2% for mixed infection. {T}he prevalence of both filariae was higher in the forest ecosystem than in savannah and lakeland (p<0.0001). {T}he intensity of microfilariae (mf) was also higher in the forest ecosystem for both parasites. {T}he prevalence and intensity of microfilaria were both influenced by age and gender. {C}orrelations were found between the prevalence and intensity of {L}oa loa microfilariae (r = 0.215 p = 0.036), and between the prevalence of {L}oa loa and the prevalence of individuals with microfilaria >8000 mf/ml (r = 0.624; p<0.0001) and microfilariae >30 000 mf/ml (r = 0.319, p = 0.002). {I}n contrast, the prevalence of pruritis and {C}alabar swellings correlated negatively with the prevalence of {L}oa loa microfilaria (r = -0.219, p = 0.032; r = -0.220; p = 0.031, respectively). {P}ruritis, {C}alabar swellings and eye worm were not associated with {L}. loa mf intensity (r = -0.144, p = 0.162; r-0.061, p = 0.558; and r = 0.051, p = 0.624, respectively), or with the prevalence or intensity of {M}. perstans microfilariae. {C}onclusions/{S}ignificance: {T}his map of the distribution of filariae in {G}abon should prove helpful for control programs. {O}ur findings confirm the spatial uniformity of the relationship between parasitological indices. {C}linical manifestations point to a relationship between filariae and allergy.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {5},
  numero = {10},
  pages = {e1329},
  ISSN = {1935-2727},
  year = {2011},
  DOI = {10.1371/journal.pntd.0001329},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00008281},
}