@article{PAR00006568, title = {{E}volution of dengue virus in {M}exico is characterized by frequent lineage replacement}, author = {{C}arrillo-{V}alenzo, {E}. and {D}anis-{L}ozano, {R}. and {V}elasco-{H}ernandez, {J}. {X}. and {S}anchez-{B}urgos, {G}. and {A}lpuche, {C}. and {L}opez, {I}. and {R}osales, {C}. and {B}aronti, {C}{\'e}cile and de {L}amballerie, {X}avier and {H}olmes, {E}. {C}. and {R}amos-{C}astaneda, {J}.}, editor = {}, language = {{ENG}}, abstract = {{B}oth dengue fever and its more serious clinical manifestation, dengue hemorrhagic fever, represent major public health concerns in the {A}mericas. {T}o understand the patterns and dynamics of virus transmission in {M}exico, a country characterized by a marked increase in dengue incidence in recent years, we undertook a molecular evolutionary analysis of the largest sample of {M}exican strains of dengue virus compiled to date. {O}ur {E} gene data set comprises sequences sampled over a period of 27 years and representing all of the {M}exican states that are endemic for dengue. {O}ur phylogenetic analysis reveals that, for each of the four dengue viruses ({DENV}-1 to {DENV}-4), there have been multiple introductions of viral lineages in {M}exico, with viruses similar to those observed throughout the {A}mericas, but there has been strikingly little co-circulation. {R}ather, dengue virus evolution in {M}exico is typified by frequent lineage replacement, such that only a single viral lineage dominates in a specific serotype at a specific time point. {M}ost lineage replacement events involve members of the same viral genotype, although a replacement event involving different genotypes was observed with {DENV}-2, and viral lineages that are new to {M}exico are described for {DENV}-1, {DENV}-3 and {DENV}-4.}, keywords = {}, booktitle = {}, journal = {{A}rchives of {V}irology}, volume = {155}, numero = {9}, pages = {1401--1412}, ISSN = {0304-8608}, year = {2010}, DOI = {10.1007/s00705-010-0721-1}, URL = {https://www.documentation.ird.fr/hor/{PAR}00006568}, }