Jansson A. M. auteur aut IRD Jakobsson E. auteur aut IRD Johansson P. auteur aut IRD Lantez V. auteur aut IRD Coutard B. auteur aut IRD de Lamballerie Xavier auteur aut IRD Unge T. auteur aut IRD Jones T. A. auteur aut IRD text journalArticle eng The Modoc virus (MODV) is a flavivirus with no known vector (NKV). Evolutionary studies have shown that the viruses in the MODV group have evolved in association with mammals (bats, rodents) without transmission by an arthropod vector. MODV methyltransferase is the first enzyme from this evolutionary branch to be structurally characterized. The high-resolution structure of the methyltransferase domain of the MODV NS5 protein (MTase(MODV)) was determined. The protein structure was solved in the apo form and in complex with its cofactor S-adenosyl-l-methionine (SAM). Although it belongs to a separate evolutionary branch, MTase(MODV) shares structural characteristics with flaviviral MTases from the other branches. Its capping machinery is a relatively new target in flaviviral drug development and the observed structural conservation between the three flaviviral branches indicates that it may be possible to identify a drug that targets a range of flaviviruses. The structural conservation also supports the choice of MODV as a possible model for flavivirus studies. specialized 052 65 Part 8 796-803 2009 0907-4449 https://www.documentation.ird.fr/hor/PAR00006540 10.1107/s0907444909017260 0907-4449 https://www.documentation.ird.fr/hor/PAR00006540 IRD - Base Horizon / Pleins textes 2011-03-23 2017-08-23 PAR00006540 fre